Expression of vascular endothelial growth factor in renal cell carcinoma is correlated with cancer advancement

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Title:	Expression of vascular endothelial growth factor in renal cell carcinoma is correlated with cancer advancement
Authors:	Yang, CC;Chu, KC;Yeh, WM
Contributors:	附設醫院泌尿部;China Med Coll Hosp, Dept Urol, China Med Coll, Taichung 404, Taiwan;China Med Coll Hosp, Dept Pathol, China Med Coll, Taichung 404, Taiwan;China Med Coll, Peikang Hosp, Dept Urol, Peikang, Taiwan
Date:	2003
Issue Date:	2010-09-24 14:31:48 (UTC+8)
Publisher:	WILEY-LISS
Abstract:	An in vitro bone cell culture model was used to evaluate the potential application of sintered beta-dicalcium pyrophosphate (SDCP) in arthroplasty surgery. Primary osteoclasts and osteoblasts were cocultured with different sizes of SDCP particles. The changes in cell counts and the synthesis and secretion of alkaline phosphatase, acid phosphatase, and prostaglandin E-2 in response to the SDCP particles were monitored. When bone cells were cultured with SDCP particles smaller than 53 mum, both the osteoblast and osteoclast cell counts decreased significantly. When the SDCP particles were larger than 177 mum, although the osteoblast population increased significantly, the osteoclast population decreased significantly. Simultaneously, the titer of prostaglandin E-2 in the medium and the cytoplasmic prostaglandin E-2 increased significantly. We concluded that SDCP is a potentially useful bioceramic for the prevention of osteoclast-mediated periprosthetic osteolysis.
Relation:	JOURNAL OF CLINICAL LABORATORY ANALYSIS 17(3):85-89
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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