Vascular endothelial growth factor gene-460 Ce/T polymorphism is a biomarker for prostate cancer

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 台中附設醫院 > 期刊論文 > Item 310903500/29312

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题名:	Vascular endothelial growth factor gene-460 Ce/T polymorphism is a biomarker for prostate cancer
作者:	Lin, CC;Wu, HC;Tsai, FJ;Chen, HY;Chen, WC
贡献者:	附設醫院泌尿部;China Med Coll Hosp, Dept Urol, Taichung 404, Taiwan;China Med Coll Hosp, Dept Med Genet, Taichung 404, Taiwan;China Med Coll Hosp, Dept Family Med, Taichung 404, Taiwan;China Med Coll Hosp, Dept Pediat, Taichung 404, Taiwan;China Med Coll Hosp, Dept Obstet & Gynecol, Taichung 404, Taiwan
日期:	2003
上传时间:	2010-09-24 14:31:44 (UTC+8)
出版者:	ELSEVIER SCIENCE INC
摘要:	Caveolin-1 (CAV-1) protein, an integral membrane protein of caveolae membranes, is highly expressed in terminally differentiated cells and down-regulated in cells transformed by human papilloma virus infection. It may also be involved in the tumorigenesis of cervical cancer. CAV-1 is regarded as a candidate for the tumor suppressor gene and it can be inactivated in several ways, including point mutations, chromosomal deletions and promoter methylation. We used direct sequencing, methylation specific PCR, and immunohistochemical staining methods to explore the role of CAV-1 gene in the development of cervical cancer. Our results showed that 4 of 72 cases (6%) had methylated CpG-island on the CAV-1 promoter, 17 of 72 cases (26.1%) having no methylation on the promoter showed no expression of CAV-1 protein, and 2 of 72 cases had a GAC-->GAT transition polymorphism at codon 82. Three types of CAV-1 expression patterns were observed in cervical cancer tissues, and the expression pattern had no relationship with mutation status. From these results, we suggest that CAV-1 gene can be inactivated through mutations, and does not play a role, through methylation of promoter, or an unknown mechanism which may play a role, in the development of cervical cancer.
關聯:	UROLOGY 62(2):374-377
显示于类别:	[台中附設醫院] 期刊論文

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