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http://ir.cmu.edu.tw/ir/handle/310903500/29304
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| 題名: | Urokinase gene 3 '-UTR T/C polymorphism is associated with urolithiasis |
| 作者: | Tsai, FJ;Lin, CC;Lu, HF;Chen, HY;Chen, WC |
| 貢獻者: | 附設醫院泌尿部;China Med Coll Hosp, Dept Urol, Taichung 404, Taiwan;China Med Coll Hosp, Dept Med Genet, Taichung 404, Taiwan;China Med Coll Hosp, Dept Pediat, Taichung 404, Taiwan;China Med Coll Hosp, Dept Family Med, Taichung 404, Taiwan;China Med Coll Hosp, Dept Obstet & Gynecol, Taichung 404, Taiwan;Natl Tsing Hua Univ, Dept Life Sci, Hsingchu, Taiwan |
| 日期: | 2002 |
| 上傳時間: | 2010-09-24 14:31:34 (UTC+8) |
| 出版者: | ELSEVIER SCIENCE INC |
| 摘要: | Adjuvant and neoadjuvant chemotherapy is being used increasingly in the treatment of breast cancer patients. However, drug-resistance plays an important role in the failure of chemotherapy in breast cancer. The aim of this study was to compare technetium-99m tetrofosmin (Tc-TETRO) mammoscintigraphic findings with the expression of drug resistance proteins (p-glycoprotein [Pgp], Ki-67 and mutant p53) in human breast cancer tissues. Thirty patients diagnosed with infiltrating ductal breast cancer underwent Tc-TETRO mammoscintigraphy before surgery or biopsy. Protein expression was investigated by immunohistochemical analyses on multiple nonconsecutive sections from surgery or biopsy specimens. Tumor to background (T/B) ratios calculated by Tc-TETRO mammoscintigraphic findings were correlated with protein expression determined by immunohistochemical analyses. The Te-TETRO T/B ratios were significantly lower for tumors in 12 patients with positive Pgp expression than for those in 18 patients with negative expression (1.19 +/- 0.13 and 1.94 +/- 0.33, p value < 0.01). However, differences in Tc-TETRO T/B ratios between the patients with positive and negative Ki-67 or mutant p53 expression were not found in this study. Our data confirmed that Tc-TETRO immunoscintigraphic findings are useful for determination of the presence of Pgp expression in breast cancer patients, but no significant relations between Tc-TETRO mammoscintigraphic findings and Ki67 or mutant p53 were found. |
| 關聯: | UROLOGY 59(3):458-461 |
| 顯示於類別: | [台中附設醫院] 期刊論文
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