Arginine form of p21 gene codon 31 is less prominent in patients with calcium oxalate stone

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Title:	Arginine form of p21 gene codon 31 is less prominent in patients with calcium oxalate stone
Authors:	Chen, WC;Lu, HF;Chen, HY;Hsu, CD;Tsai, FJ
Contributors:	附設醫院泌尿部;China Med Coll Hosp, China Med Coll, Sch Med, Dept Urol, Taichung, Taiwan;China Med Coll Hosp, China Med Coll, Sch Med, Dept Obstet & Gynecol, Taichung, Taiwan;China Med Coll Hosp, China Med Coll, Sch Med, Dept Med Genet, Taichung, Taiwan;Natl Tsing Hua Univ, Inst Life Sci, Hsinchu, Taiwan
Date:	2001
Issue Date:	2010-09-24 14:31:26 (UTC+8)
Publisher:	SPRINGER-VERLAG
Abstract:	The formation of urinary stones is presumed to be associated with polymorphism of the osteocalcin gene. The most frequently seen polymorphism is the Hind III type located at the promoter region. This polymorphism has been used as a genetic marker in the search for a correlation between urolithiasis and normal subjects. in our study, a normal control group of 105 healthy people and 102 patients with calcium oxalate stones were examined. The polymorphism was seen following polymerase chain reaction-based restriction analysis. The results revealed no significant differences between normal individuals and stone patients (P = 0.978), and distribution of the TT homozygote in the control group (42.9%) was similar to that in the patient group (42.2%). Further categorization of the stone patients into normocalciuric and hypercalciuric groups also revealed no statistical differences from controls. We conclude that Hind III polymorphism of the osteocalcin gene is not a suitable genetic marker of urinary stone disease. Further searches for other polymorphisms on this gene correlated with stone disease are suggested.
Relation:	UROLOGICAL RESEARCH 29(2):94-97
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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