The reappraisal of nephrocalcin - its role in the inhibition of calcium oxalate crystal growth and interaction with divalent metal ions

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Title:	The reappraisal of nephrocalcin - its role in the inhibition of calcium oxalate crystal growth and interaction with divalent metal ions
Authors:	Chang, LC;Lin, HS;Chen, WC
Contributors:	附設醫院泌尿部;Natl Tsing Hua Univ, Inst Life Sci, Hsinchu, Taiwan;China Med Coll Hosp, China Med Coll, Sch Med, Dept Urol, Taichung, Taiwan
Date:	2001
Issue Date:	2010-09-24 14:31:25 (UTC+8)
Publisher:	SPRINGER-VERLAG
Abstract:	The formation of urinary stones is associated with cell death in response to various injuries. P21 (WAFI/CIP1) is a downstream protein of P53 and can arrest the cell cycle at G1/S with resulting cell death. We aimed to investigate the polymorphism of p21 gene codon 31 as the genetic marker in searching for the association of urolithiasis. One hundred and nineteen healthy controls and 95 patients with calcium oxalate stone were examined in this study. The polymorphism was seen from the result of polymerase chain reaction-based restriction analysis. The result revealed significant differences between normal individuals and stone patients (P < 0.05) and the distribution of arginine homozygote in the control group (31.9%) was higher than in the patient group (16.80%). It is concluded that polymorphisms of p21 codon 31 can be a genetic marker for urinary stone disease. Individuals possessing arginine form of p21 codon 31 have less risk of developing calcium stone disease.
Relation:	UROLOGICAL RESEARCH 29(2):89-93
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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