Effects of the butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT) on the arylamines N-acetyltransferase activity in rat white blood cells

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Title:	Effects of the butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT) on the arylamines N-acetyltransferase activity in rat white blood cells
Authors:	Lu, HF;Wu, HC;Chang, WC;Chung, JG
Contributors:	附設醫院泌尿部;China Med Coll Hosp, Dept Urol, Taichung 400, Taiwan;China Med Coll, Dept Med, Taichung 400, Taiwan;China Med Coll, Inst Med Res, Taichung 400, Taiwan
Date:	1999
Issue Date:	2010-09-24 14:31:19 (UTC+8)
Publisher:	FACULTY PRESS
Abstract:	The objectives of this study were to analyse and identify the metabolites of diallyl disulfide (DADS) and diallyl sulfide (DAS) in primary rat hepatocytes prepared by collagenase perfusion. According to the results, allyl mercaptan (AM) and allyl methyl sulfide (AMS) were the metabolites of DADS. The highest amount of AMS (0.93 +/- 0.08 mu g/ml at 90 min) was much less than that of AM (46.2 +/- 6.6 mu g/ml at 60 min). Combined with the Purge and Trap using a gas chromatography-mass spectrometry (GC-MS) system, it is very useful to detect the trace amounts of metabolites in primary rat hepatocytes. Results also showed that AMS was a metabolite of DAS. The highest amount of AMS in the extracellular fluid of hepatocytes was 0.63 +/- 0.16 mu g/ml at 30 min of incubation. (C) 2000 Elsevier Science Ltd. All rights reserved.
Relation:	CYTOBIOS 100(395):159-169
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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