Hepatic steatosis and pancreatitis associated with the use of stavudine in a patient with HIV infection

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 台中附設醫院 > 期刊論文 > Item 310903500/29294

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题名:	Hepatic steatosis and pancreatitis associated with the use of stavudine in a patient with HIV infection
作者:	Lai, HY;Chen, JH;Tsai, PP;Ho, MW;Shen, WC
贡献者:	附設醫院放射線部;China Med Univ Hosp, Dept Radiol, Taichung 404, Taiwan;China Med Univ Hosp, Dept Internal Med, Taichung 404, Taiwan
日期:	2004
上传时间:	2010-09-24 14:31:18 (UTC+8)
出版者:	AMER ROENTGEN RAY SOC
摘要:	2-Benzyloxybenzaldehyde (CCY1a) inhibited the formyl-Met-Leu-Phe (fMLP)-induced elevation of cytosolic [Ca2+] ([Ca2+](i)) in rat neutrophils. The late plateau phase, but not the initial Ca2+ spike, of the fMLP-induced [Ca2+](i) change was inhibited by CCY1a. In the absence of external Ca2+, CCY1a had no appreciable effect on either the fMLP- or cyclopiazonic acid (CPA)-induced [Ca2+](i) elevation. CCY1a failed to inhibit [Ca2+](i) changes induced by N-ethylmaleimide, GEA3162, ionomycin or sphingosine, but slightly inhibited the Ca2+ signals elicited by ATP or interleukin-8 (IL-8). In a classical Ca2+ readdition protocol, addition of CCY1a after cell activation strongly inhibited the [Ca2+](i) response to fMLP, whilst that to CPA was only slightly reduced. CCY1a nearly abrogated the fMLP-stimulated Mn2(+) influx but was less effective on the CPA-induced response. CCY1a attenuated the levels of tyrosine-phosphorylated bands in the 70-85 kDa molecular mass range. CCY1a had no effect on the basal [Ca2+](i) level, the pharmacologically isolated plasma membrane Ca2+-ATPase activity or on the mitochondrial membrane potential. Thus, CCY1a blocks fMLP-induced Ca2+ entry into neutrophils probably by blocking the relevant Ca2+ channel directly or, alternatively, indirectly through the attenuation of tyrosine phosphorylation of some cellular proteins.
關聯:	AMERICAN JOURNAL OF ROENTGENOLOGY 183(6):1605-1607
显示于类别:	[台中附設醫院] 期刊論文

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