Boron-lipiodol: A potential new drug for the treatment of liver tumors

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Title:	Boron-lipiodol: A potential new drug for the treatment of liver tumors
Authors:	Lin, WY;Chi, CW;Ho, YJ;Wu, IC;Chung, YT;Chen, SD;Chou, FI;Kai, JJ;Lui, WY;Chen, TJ;Lin, YC
Contributors:	附設醫院放射線部;Natl Chung Hsing Univ, Dept Vet Med, Taichung 40227, Taiwan;Natl Chung Hsing Univ, Inst Vet Pathol, Taichung 40227, Taiwan;Taichung Vet Gen Hosp, Dept Nucl Med, Taichung 40705, Taiwan;Taipei Vet Gen Hosp, Dept Med Res & Educ, Taipei 11217, Taiwan;Taipei Vet Gen Hosp, Dept Surg, Taipei 11217, Taiwan;Natl Yang Ming Univ, Taipei 11217, Taiwan;China Med Coll Hosp, Dept Radiol, Taichung 40402, Taiwan;Jen Ai Gen Hosp, Taichung, Taiwan;Natl Tsing Hua Univ, Nucl Sci & Technol Dev Ctr, Isotope Div, Hsinchu 30013, Taiwan;Natl Tsing Hua Univ, Dept Engineer & Syst Sci, Hsinchu 30013, Taiwan;Inst Nucl Energy Res, Lung Tan, Taiwan
Date:	2002
Issue Date:	2010-09-24 14:30:55 (UTC+8)
Publisher:	INT INST ANTICANCER RESEARCH
Abstract:	The purpose of this study was to prepare and evaluate the feasibility and biocompatibility of a new composite as a bone substitute. The new composite (GTGC) was mainly composed of tricalcium phosphate ceramics and gelatin to which Chi-Li-Saan, a Chinese medicinal remedy was added. The GTGC composite was manually packed into cylindrical Teflon molds, dried overnight in an oven and sterilized by gamma-ray prior to use. Mature New Zealand rabbits, weighting 3-3.5 kg, underwent full-thickness excision of the parietal bone. In the experimental group, bone defects of 12 animals were filled with the GTGC composites and another 12 unreconstructed rabbits were considered as controls. Three rabbits were examined for each group in every time period at 2, 4, 8 and 12 weeks after operation. There was no evidence of adverse tissue reaction to the GTGC composite. In addition, examination with light and fluorescent microscopy revealed a significantly greater amount of new bone ingrowth in the GTGC group at the same implantion time as compared with the controls. Therefore, the GTGC composite could serve as a useful substitute when repairing bone defects.
Relation:	ANTICANCER RESEARCH 22(6C):3989-3992
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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