中國醫藥大學機構典藏 China Medical University Repository, Taiwan:Item 310903500/29283
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    题名: Asymptomatic arterio-biliary fistula after transarterial chemoembolization of metastatic liver tumors
    作者: Chen, JH;Ho, YJ;Shen, WC
    贡献者: 附設醫院放射線部;China Med Coll Hosp, Dept Radiol, Taichung 404, Taiwan;Jen Ai Gen Hosp, Dept Radiol, Taichung, Taiwan
    日期: 2001
    上传时间: 2010-09-24 14:30:52 (UTC+8)
    出版者: H G E UPDATE MEDICAL PUBL LTD.
    摘要: The objective of this study was to investigate the effect of the active principles in garlic-diallyl sulfide (DAS) and diallyl disulfide (DADS)-on aflatoxin B-1 (AFB(1))-induced DNA damage in primary rat hepatocytes. Primary rat hepatocytes, induced with DNA damage using 10 muM AFB(1) were used as an experimental model. According to the results of LDH leakage, 0.5 and 2 mM of DAS or 0.5 and 1 mM of DADS significantly increased the viability of hepatocytes compared with the AFB(1) controls after 4, 8 and 24 h treatment (P <0.05). According to the results of unscheduled DNA synthesis (UDS) test. 0.5 and 2 mM of DAS or 0.5 acid 1 mM of DADS could significantly decrease the DNA damage induced by AFB(1) (P<0.05). Furthermore, 0.5 and 2 mM DAS or 0.5 and 1 mM DADS could increase the glutathione S-transferase (GST) and glutathione peroxidase (GPx) activities as compared with the AFB(1) controls after 24 h treatment (P<0.05). Results of immunoblot analysis of cytosolic GST isoenzyme indicate that the levels of GST isoform Ya, Yb2 and Yc were markly increased after treatment with 0.5 and 2 mM DAS or 0.5 and 1 mM DADS compared with the AFB(1) control. These results indicate that 0.5 and 2 mM DAS or 0.5 and 1 mM DADS might protect hepatocytes from AFB(1)-induced DNA damage via increasing the activities of GST and GPx. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
    關聯: HEPATO-GASTROENTEROLOGY 48(39):842-843
    显示于类别:[台中附設醫院] 期刊論文

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