Persistent mullerian duct syndrome with seminoma: CT findings

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 台中附設醫院 > 期刊論文 > Item 310903500/29280

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题名:	Persistent mullerian duct syndrome with seminoma: CT findings
作者:	Wu, HC;Chen, JH;Lu, HF;Shen, WC
贡献者:	附設醫院放射線部;China Med Coll Hosp, Dept Radiol, Taichung 404, Taiwan;China Med Coll Hosp, Dept Urol, Taichung 404, Taiwan
日期:	2000
上传时间:	2010-09-24 14:30:47 (UTC+8)
出版者:	AMER ROENTGEN RAY SOC
摘要:	Aberrant transcripts of FHIT and TSG101 using nested RT-PCR were reported in many human tumours. The role of these aberrant transcripts in tumourigenesis is not clear. We, therefore, analyzed the aberrant transcripts of FHIT, TSG101 and PTEN/MMAC1 in peripheral mononuclear cells of normal individuals using nested RT-PCR to explore the role of these genes in cancer development. The results showed that there are at least five types of aberrant transcripts: type I is the deletion at junction located in-between normal exon and intron; type II has deletion of some bases and subsequent insertion of several bases in the deletion area; type III accommodates splicing donor or acceptor site-like sequence; type IV has homologous sequences near the deleted junction; and type V comprises the homologous sequences at the deletion junction. A normal healthy person can have more than one aberrant transcripts of FHIT, TSG101 and PTEN/MMAC1 genes. The size and the number of the transcripts vary and the diversity is unconstrained. It is not depended on the time, condition of the reaction, or the isolation method. From these results, we suggested that the aberrant transcripts of FHIT, TSG101 and PTEN/MMAC1 genes may be the imperfect products of splicesome which occur one in every thousands, ten thousands or more. As a result, these data implied no direct association between the aberrant transcripts and tumourigenesis.
關聯:	AMERICAN JOURNAL OF ROENTGENOLOGY 174(1):102-104
显示于类别:	[台中附設醫院] 期刊論文

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