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請使用永久網址來引用或連結此文件:
http://ir.cmu.edu.tw/ir/handle/310903500/29273
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| 題名: | Dynamic helical biphasic CT emerges as a potential tool for the diagnosis of proximal arterioportal shunting |
| 作者: | Chen, JH;Huang, CL;Hwang, JI;Lee, SK;Shen, WC |
| 貢獻者: | 附設醫院放射線部;China Med Coll Hosp, Dept Radiol, Taichung, Taiwan;Taichung Vet Gen Hosp, Dept Radiol, Taichung, Taiwan |
| 日期: | 1999 |
| 上傳時間: | 2010-09-24 14:30:21 (UTC+8) |
| 出版者: | H G E UPDATE MEDICAL PUBL LTD. |
| 摘要: | The signaling pathways leading to extracellular signal-regulated kinase (ERK) activation in formyl-methionyl-leucyl-phenylalanine (fMLP)-stimulated rat neutrophils were examined. fMLP-stimulated ERK activation based on immunoblot analysis with antibodies against the phosphorylation form of ERK was attenuated by the pretreatment of cells with pertussis toxin but not with a dual cyclo-oxygenase/lipoxygenase inhibitor BW755C. Exposure of cells to the tyrosine kinase inhibitor genistein, phosphatidylinositol 3-kinase (PI3K) inhibitors wortmannin and LY294002, or protein kinase C (PKC) inhibitors Go6976, Go6983, and GF109203X inhibited fMLP-stimulated ERK phosphorylation in a concentration-dependent manner. In addition, both the phospholipase C (PLC) inhibitor U73122 and the Ca2+ chelator BAPTA attenuated ERK activation. These results indicate that G(i/o) protein, tyrosine kinase, PI3K, PKC, and PLC/Ca2+, but not arachidonate metabolites, act upstream of fMLP-stimulated ERK activation. (C) 1999 Federation of European Biochemical Societies. |
| 關聯: | HEPATO-GASTROENTEROLOGY 46(27):1791-1797 |
| 顯示於類別: | [台中附設醫院] 期刊論文
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