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    題名: Myelination arrest demonstrated using magnetic resonance imaging in a child with type I G(M1) gangliosidosis
    作者: Shen, WC;Tsai, FJ;Tsai, CH
    貢獻者: 附設醫院放射線部;China Med Coll Hosp, Dept Radiol, Taichung 401, Taiwan;China Med Coll, Sch Med, Taichung, Taiwan;China Med Coll Hosp, Dept Pediat, Taichung, Taiwan
    日期: 1998
    上傳時間: 2010-09-24 14:30:05 (UTC+8)
    出版者: EXCERPTA MEDICA ASIA LTD
    摘要: Arylamine N-acetyltransferase (NAT) activities with 2-aminofluorene and p-aminobenzoic acid were determined in the bacterium Helicobacter pylori collected from peptic ulcer patients, Cytosols or suspensions of H. pylori with or without specific concentrations of rhein co-treatment showed different percentages of 2-aminofluorene and p-aminobenzoic acid acetylation. The data indicate that there was decreased NAT activity associated with increased levels of rhein in H. pylori cytosols, Inhibition of growth studies from H. pylori demonstrated that rhein elicited dose-dependent bacteriostatic activity in H. pylori cultures: i.e. the greater the concentration of rhein, the greater the inhibition of growth to H. pylori. For the cytosol and intact bacteria examination, the apparent values of K-m and V-max were decreased after co-treatment with 40 mu M rhein, This report is the first demonstration of rhein inhibition of arylamine N-acetyltransferase activity and rhein inhibition of growth in the bacterium H. pylori. (C) 1998 John Wiley & Sons, Ltd.
    關聯: JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION 97(4):296-299
    顯示於類別:[台中附設醫院] 期刊論文

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