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http://ir.cmu.edu.tw/ir/handle/310903500/29265
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| 題名: | Comparative dosimetric study of two strategies of intensity-modulated radiotherapy in nasopharyngeal cancer |
| 作者: | Chen, SW;Yang, SN;Liang, JA;Shiau, AC;Lin, FJ |
| 貢獻者: | 附設醫院放射腫瘤科;China Med Univ Hosp, Dept Radiat Therapy & Oncol, Taichung, Taiwan;China Med Univ, Sch Med, Taichung, Taiwan;Natl Taiwan Univ, Sch Med, Taipei 10764, Taiwan;Natl Yang Ming Univ, Sch Med Technol & Engn, Taipei 112, Taiwan |
| 日期: | 2005 |
| 上傳時間: | 2010-09-24 14:29:56 (UTC+8) |
| 出版者: | ELSEVIER SCIENCE INC |
| 摘要: | Naltrexone, a nonselective antagonist of opioid receptors, is found to be beneficial in protecting against heatstroke. Further investigation using selective mu, delta, and kappa opioid receptor antagonists are needed to prove the involvement of specific receptors in heatstroke. Rats under sodium pentobarbital anesthesia were exposed to high ambient temperature of 43 degrees C to induce heatstroke. Control rats were exposed to 24 degrees C. In rats treated with normal saline 20 minutes before heat stress, the values for survival time were found to be 89-101 minutes. Intravenous administration of CTAP (a selective mu-opioid receptor antagonist; 50-200 mu g/kg), but not nor-binaltorphimine (20-200 mu g/kg; a kappa-Opioid receptor antagonist) or ICI-174864 (50-500 mu g/kg; a delta-opioid receptor antagonist), significantly increased the survival time to new values of 180-212 minutes. In vehicle-treated rats after heatstroke onset, the values for core temperature, intracranial pressure, and the extracellular markers for ischemia (eg, glutamate and lactate/pyruvate ratio) or damage (eg, glycerol) and neuronal damage scores in striatum were significantly higher than those of normothermic controls. In contrast, the values for mean arterial pressure, cerebral perfusion pressure, cerebral blood flow, and brain partial pressure of O-2 were significantly lower than those of normothermic controls. The heatstroke-induced hyperthermia, arterial hypotension, intracranial hypertension, cerebral hypoperfusion and hypoxia, and increased levels of cellular ischemia and damage markers in striatum were all significantly attenuated by prior administration of CTAP. The data indicate that prior antagonism of mu-opioid receptors protects against circulatory shock and cerebral ischemia during heatstroke. |
| 關聯: | MEDICAL DOSIMETRY 30(4):219-227 |
| 顯示於類別: | [台中附設醫院] 期刊論文
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