 |
English
|
正體中文
|
简体中文
|
全文筆數/總筆數 : 29490/55136 (53%)
造訪人次 : 1996020
線上人數 : 508
|
|
|
資料載入中.....
|
請使用永久網址來引用或連結此文件:
http://ir.cmu.edu.tw/ir/handle/310903500/29251
|
| 題名: | Efficacy and safety of modified Mai-Men-Dong-Tang for treatment of allergic asthma |
| 作者: | Hsu, CH;Lu, CM;Chang, TT |
| 貢獻者: | 附設醫院兒科部;China Med Univ Hosp, Dept Pediat, Taichung 404, Taiwan;TaiMont Biotec Inc, Tainan, Taiwan;China Med Univ, Inst Chinese Med Sci, Taichung, Taiwan |
| 日期: | 2005 |
| 上傳時間: | 2010-09-24 14:28:55 (UTC+8) |
| 出版者: | BLACKWELL MUNKSGAARD |
| 摘要: | JUNB is an activating protein-1 transcription factor and is important in the control of cell growth, differentiation and neoplastic transformation. To understand the role of JUNB in human hepatocellular carcinoma (HCC), we examined 30 HCCs and their paired non-cancerous tissues by real-time quantitative reverse transcription-polymerase chain reaction and immunohistochemical analysis for the expression of JUNB. The results showed that JUNB was underexpressed in most of the cancerous tissues (73.3%). Mutational analysis of the entire gene, and methylation analysis of CpG sites at the promoter area of JUNB, showed no specific changes between cancerous and paired non-cancerous tissues. Our results suggest that the down-regulated JUNB expression in HCC was due to an unknown mechanism, and not to methylation of the CpG site at the promoter or mutation in the coding areas. We further analyzed the relationship between JUNB, P16 and cyclin D1 expression. Our results showed that JUNB and P16 produced similar expression patterns, however, inverse expression patterns were found between JUNB and cyclin D1 in most of the HCC tissues. We also found a discrepancy between the expression of JUNB and cyclin D1 in some of the HCC tissue. From these results, we suggest that two pathways (JUNB-related and JUNB-unrelated) may be involved in the development of HCC. |
| 關聯: | PEDIATRIC ALLERGY AND IMMUNOLOGY 16(1):76-81 |
| 顯示於類別: | [台中附設醫院] 期刊論文
|
在CMUR中所有的資料項目都受到原著作權保護.
|
