Estrogen receptor alpha dinucleotide repeat and cytochrorne P450c17 alpha gene polymorphisms are associated with susceptibility to endometriosis

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Title:	Estrogen receptor alpha dinucleotide repeat and cytochrorne P450c17 alpha gene polymorphisms are associated with susceptibility to endometriosis
Authors:	Hsieh, YY;Chang, CC;Tsai, FJ;Lin, CC;Tsai, CH
Contributors:	附設醫院兒科部;China Med Univ Hosp, Dept Pediat & Med Genet, Taichung, Taiwan;China Med Univ Hosp, Dept Obstet & Gynecol, Taichung, Taiwan;Natl Chiao Tung Univ, Dept Biol Sci & Technol, Hsinchu, Taiwan;Taichung Hlth Care & Management Univ, Taichung, Taiwan
Date:	2005
Issue Date:	2010-09-24 14:28:43 (UTC+8)
Publisher:	ELSEVIER SCIENCE INC
Abstract:	Snoring is the most obvious symptom of sleep-disordered breathing (SDB). Vibratory sound usually originates from the pharynx; however, in some circumstances, the narrowing of glottic structures can also cause nighttime breathing noise. This clinical study investigated the role of laryngeal obstruction in patients with SDB. Nine female patients with paralysis of bilateral vocal folds were enrolled in this study. All the patients received unilateral laser arytenoidectomy as the only treatment. Nocturnal polysomnography (PSG) was performed at baseline and 6 months after the operation. Parameters of PSG including the respiratory disturbance index (RDI) and snoring index (SI) were recorded, as well as the subjective Epworth Sleepiness Scale (ESS). Before surgery, six patients (66.6%) were identified as having obstructive sleep apnea (OSA, RDI > 5). After the operation, the SI improved significantly (P=0.02). The RDI (P=0.07) and ESS (P=0.11) showed no significant improvement. The success rate of surgery in OSA patients was 66% (4/6) according to the criteria of a greater than 50% reduction of the preoperative RDI and less than 20 events per hour. The mechanism, outcomes and causes of failure are discussed in this unusual larynx-related SDB.
Relation:	FERTILITY AND STERILITY 83(3):567-572
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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