Polymorphism of angiotensin-1 converting enzyme gene and Kawasaki disease

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 台中附設醫院 > 期刊論文 > Item 310903500/29221

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题名:	Polymorphism of angiotensin-1 converting enzyme gene and Kawasaki disease
作者:	Wu, SF;Chang, JS;Peng, CT;Shi, YR;Tsai, FJ
贡献者:	附設醫院兒科部;China Med Univ Hosp, Dept Pediat, Taichung, Taiwan
日期:	2004
上传时间:	2010-09-24 14:27:39 (UTC+8)
出版者:	SPRINGER
摘要:	Although the underlying mechanism is not elucidated, it has been postulated repeatedly that deprivation of sleep, particularly rapid eye movement (REM) sleep, affects learning. Here we report that memory for newly acquired information is impaired after a specific period of REM sleep deprivation (REMD). Memory retrieval-induced phosphorylation of protein kinases in the rat amygdala is abrogated by REMD that is associated with an increase in the expression of a dual protein/lipid phosphatase PTEN. REMD given before training is without effect, suggesting the lack of effect on the acquisition of memory. Intra-amygdala administration of antisense but not sense or scrambled oligonucleotides for PTEN prevents REMD-induced decrease in protein phosphorylation and impairment of fear memory. Thus, REMD interferes with the process of memory retention via the activation of PTEN.
關聯:	PEDIATRIC CARDIOLOGY 25(5):529-533
显示于类别:	[台中附設醫院] 期刊論文

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