Lack of association of genetic polymorphisms in the interleukin-1 beta, interleukin-1 receptor antagonist, interleukin-4 and interleukin-10 genes with mitral valve prolapse in Taiwan Chinese

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Title:	Lack of association of genetic polymorphisms in the interleukin-1 beta, interleukin-1 receptor antagonist, interleukin-4 and interleukin-10 genes with mitral valve prolapse in Taiwan Chinese
Authors:	Chou, HT;Shi, YR;Hsu, Y;Tsai, FJ
Contributors:	附設醫院兒科部;China Med Coll Hosp, Dept Pediat, Taichung 404, Taiwan;China Med Coll Hosp, Dept Med, Div Cardiol, Taichung 404, Taiwan
Date:	2003
Issue Date:	2010-09-24 14:27:14 (UTC+8)
Publisher:	I C R PUBLISHERS
Abstract:	Background/Aims. It has been speculated that impaired salivary flow contributes to autoimmune thyroiditis (chronic thyroiditis, Hashimoto's thyroiditis). To test this hypothesis, salivary function was measured by quantitative salivary scintigraphy in autoimmune thyroiditis patients, as well as in age- and gender-matched controls for comparison. Methodology. One hundred and twenty patients with an autoimmune thyroiditis history of more than 10 years each and 36 healthy controls were enrolled in the study. All the 120 autoimmune thyroiditis patients had good blood sugar control. None had autonomic neuropathy. These 120 autoimmune thyroiditis patients were separated into two subgroups: group 1, 60 patients with xerostomia; and group 2, 60 patients without xerostomia. After intravenous injection of 5 mCi Tc-99m pertechnetate, sequential images at 1 min/frame were acquired for 30 min. The first- and 15th-minute uptake ratios (UR) were calculated from the tracer uptakes in the four major salivary glands over the background regions of interest (ROIs). Saliva excretion was stimulated by 1 tablet of 200 mg ascorbic acid given orally 15 min after injection of the tracer. Then, the maximal excretion ratios (ER) of the four major salivary glands after sialagogue stimulation were calculated. Results. Impaired salivary function, represented by significantly decreased UR and ER values, in autoimmune thyroiditis patients with xerostomia was demonstrated in this study. In addition, there was a significantly higher prevalence of salivary gland dysfunction in group 1 patients than in group 2 patients. Conclusions. Significantly poorer salivary function was found in autoimmune thyroiditis patients with xerostomia compared with autoimmune thyroiditis patients without xerostomia and healthy controls by means of objective and quantitative salivary scintigraphy. (C) 2003 Wiley Periodicals, Inc.
Relation:	JOURNAL OF HEART VALVE DISEASE 12(1):38-44
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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