Association of an A allele for interieukin-10-627 gene promoter polymorphism with higher susceptibility to endometriosis

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Title:	Association of an A allele for interieukin-10-627 gene promoter polymorphism with higher susceptibility to endometriosis
Authors:	Hsieh, YY;Chang, CC;Tsai, FJ;Lin, CC;Tai, CT;Ho, M
Contributors:	附設醫院兒科部;China Med Coll Hosp, Dept Pediat & Med Genet, Taichung, Taiwan;China Med Coll Hosp, Dept Obstet & Gynecol, Taichung, Taiwan
Date:	2003
Issue Date:	2010-09-24 14:26:41 (UTC+8)
Publisher:	SCI PRINTERS & PUBL INC
Abstract:	Immuno-electron microscopy specifically enhanced with silver staining has been used to demonstrate the localization of calcitonin gene-related peptide (CGRP) in the ependymocytes of the hamster subcommissural organ (SCO). Hamster SCO consists of the ependymal and hypendymal cell layers, the latter being arranged as rosette-like structure across the posterior commissure (PC) and often arranged with longitudinal axis parallel to the ventricle. All cytoplasmic regions of the ependymal and hypendymal cells were strongly stained with CGRP. In the hypendymal layer, the CGRP positive hypendymal cells were frequently in contact with local blood vessels and arranged in-groups traversing the thick portion of the PC. Ultrastructurally, the CGRP-immunoreaction products were distributed at the dilated cisternae of the rough endoplasmic reticulum (rER) and secretory granules of the ependymal and hypendymal cells. The dilated cisterna of the rER was usually concentrated in the basal region of the ependymal cells and irregular in shape. These dilated cisternae were filled with a flocculent material or finely granular substance, but hardly studded with ribosomes. Labelled secretory granules were abundant in the apical pole of the ependymal cells and discharged their contents into the third ventricle in the form of a thin layer of secretion. This CGRP positive material appeared to constitute the pre-Reissner's fiber (RF). On the basis of the present ultrastructural evidences, we proposed that ependymocytic CGRP in SCO may be synthesized and stored in the cisternae of rER, then released and incorporated into the RF in the third ventricle through the secretory granules. The abundant amount of CGRP in ependymocytes of SCO and RF in the third ventricle suggests a significant endocrine function of CGRP in hamster SCO. (C) 2003 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
Relation:	JOURNAL OF REPRODUCTIVE MEDICINE 48(9):735-738
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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