The polymorphisms of codon 727 and 52 of thyroid-stimulating hormone receptor gene are not associated with mitral valve prolapse syndrome in Taiwan Chinese

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 台中附設醫院 > 期刊論文 > Item 310903500/29188

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题名:	The polymorphisms of codon 727 and 52 of thyroid-stimulating hormone receptor gene are not associated with mitral valve prolapse syndrome in Taiwan Chinese
作者:	Chou, HT;Shi, YR;Chang, CT;Tsai, FJ
贡献者:	附設醫院兒科部;China Med Coll Hosp, Dept Pediat Med Res & Med Genet, Taichung, Taiwan;China Med Coll Hosp, Div Cardiol, Taichung, Taiwan;China Med Coll Hosp, Div Endocrinol & Metab, Dept Med, Taichung, Taiwan
日期:	2002
上传时间:	2010-09-24 14:26:02 (UTC+8)
出版者:	JAPAN HEART JOURNAL, SECOND DEPT OF INTERNAL MED
摘要:	In this study, technetium-(99m) ethyl cysteinate dimer (Tc-99m ECD) brain single photon emission computed tomography (SPECT) was used to detect regional cerebral blood flow (rCBF) of the brain in SLE patients with normal brain magnetic resonance imaging (MRI) findings. Twenty female SLE patients were enrolled in this study, divided into two groups. Group 1 consisted of 10 patients with neuropsychiatric manifestations. Group 2 consisted of 10 patients without neuropsychiatric manifestations. All patients had normal brain MRI findings. Another 10 SLE patients with abnormal MRI findings were included as group 3 for comparison. Meanwhile, 10 healthy female volunteers also underwent brain MRI and Tc-99m ECD brain SPECT for comparison. The scans revealed hypoperfusion lesions in 9/20 (45%) SLE patients, including 7/10 (70%) cases in group 1 and 2/10 (20%) cases in group 2. In contrast all 10 patients (100%) in group 3 had abnormal Tc-99m ECD brain SPECT findings. The parietal lobes were the most commonly involved areas. We conclude that Tc-99m ECD brain SPECT is more sensitive for detecting rCBF changes than is brain MRI in detecting the brain anatomic changes, and may have a diagnostic value in lupus cerebral involvement. However, 99mTc ECD brain SPECT may not be indicated for SLE patients with normal MRI and mild neuropsychiatric symptoms/signs, such headaches and dizziness.
關聯:	JAPANESE HEART JOURNAL 43(6):655-666
显示于类别:	[台中附設醫院] 期刊論文

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