Infantile form G(M1) gangliosidosis with dilated cardiomyopathy: a case report

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题名:	Infantile form G(M1) gangliosidosis with dilated cardiomyopathy: a case report
作者:	Lin, HC;Tsai, FJ;Shen, WC;Tsai, CH;Peng, CT
贡献者:	附設醫院兒科部;China Med Coll Hosp, Dept Pediat, Taichung 404, Taiwan;China Med Coll Hosp, Dept Radiol, Taichung 404, Taiwan
日期:	2000
上传时间:	2010-09-24 14:25:42 (UTC+8)
出版者:	TAYLOR & FRANCIS AS
摘要:	Carmustine and lomustine are nitrosourea antitumor chemotherapeutic agents which were used to determine whether or not they could affect arylamine N-acetyltransferase (NAT) activity and DNA-2-aminofluorene adducts in rat glial tumor cell line (C6 glioma). The NAT activity was measured by high preformance liquid chromatography (HPLC) assaying for the amounts of N-acetyl-2-aminofluorene (AAF) and N-acetyl-p-aminobenzoic acid (N-Ac-PABA) and remaining 2-aminofluorene (AF) and p-aminobenzoic acid (PABA). The results indicate that NAT activity in glial tumor cell cytosols and intact tumor cells were decreased by carmustine and lomustine in a dose-dependent manner. The apparent values of Km and Vmax of NAT from rat glial tumor cell also decreased after co-treatment of carmustine and lomustine in both examined cytosols and intact cells. Following exposure of glial tumor cells to the various concentrations of AF with or without co-treatment with carmustine and lomustine, DNA-AF adducts were determined by using gamma-[(32)p]-dATP and HPLC. The DNA-AF adducts in rat glial tumor cells were decreased by co-treatment with carmustine and lomustine. This report is the first demonstration to show carmustine and lomustine did inhibit rat glial tumor cells NAT activity and DNA-AF adduct formation.
關聯:	ACTA PAEDIATRICA 89(7):880-883
显示于类别:	[台中附設醫院] 期刊論文

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