Catabolic effect in premature infants with early dexamethasone treatment

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 台中附設醫院 > 期刊論文 > Item 310903500/29163

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题名:	Catabolic effect in premature infants with early dexamethasone treatment
作者:	Tsai, FJ;Tsai, CH;Wu, SF;Liu, YH;Yeh, TF
贡献者:	附設醫院兒科部;CHINA MED COLL HOSP,PEDIAT RES LAB,TAICHUNG,TAIWAN;NATL CHENG KUNG UNIV HOSP,TAINAN,TAIWAN
日期:	1996
上传时间:	2010-09-24 14:24:48 (UTC+8)
出版者:	SCANDINAVIAN UNIVERSITY PRESS
摘要:	2-Chloro-3-methoxycarbonylpropionamido-1,4-naphthoquinone (PP1D1) produced a dose-dependent inhibition of the polymyxin B-induced hind-paw edema in normal as well as in adrenalectomized mice. A comparable inhibitory profile was observed in mice to which PP1D1 was injected i.p. or applied orally. Unlike dexamethasone, PP1D1 had no effect on the liver glycogen content in fasting adrenalectomized mice. Ear edema caused by passive cutaneous anaphylactic reaction, or by subcutaneous injection of compound 48/80, histamine, serotonin, bradykinin or substance P was reduced by PP1D1 in a dose-dependent manner. In addition, topical application of PP1D1 suppressed the capsaicin- and arachidonic acid-induced ear edema. In compound 48/80-pretreated mice, the tissue histamine content was greatly reduced. Under these conditions, PP1D1 reduced the bradykinin- and substance P-induced ear edema to a significantly greater extent than diphenhydramine plus methysergide. These results suggest that the inhibitory effect of PP1D1 on the edematous response is due to the protection of the microvasculature from mediator challenge.
關聯:	ACTA PAEDIATRICA 85(12):1487-1490
显示于类别:	[台中附設醫院] 期刊論文

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