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資料載入中.....
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請使用永久網址來引用或連結此文件:
http://ir.cmu.edu.tw/ir/handle/310903500/29156
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| 題名: | Relationship of preoperative findings and ossicular discontinuity in chronic otitis media |
| 作者: | Jeng, FC;Tsai, MH;Brown, CJ |
| 貢獻者: | 附設醫院耳鼻喉部;Univ Iowa, Dept Speech Pathol & Audiol, Iowa City, IA 52242 USA;China Med Coll Hosp, Dept Otolaryngol, Taichung, Taiwan |
| 日期: | 2003 |
| 上傳時間: | 2010-09-24 14:24:28 (UTC+8) |
| 出版者: | LIPPINCOTT WILLIAMS & WILKINS |
| 摘要: | Uterine leiomyomas are the most common benign uterine tumors in the women of reproductive age. Previous studies have suggested that uterine leiomyomas are monoclonal tumors derived from a single neoplastic myometrial cell. However, the neoplastic transformation of myometrium to leiomyomas remains to be elucidated. The classical cadherins are a gene family of integral membrane glycoproteins that mediate calcium-dependent cell-cell adhesion in a homophilic manner. These cell adhesion molecules (CAMs) have been shown to play pivotal roles in tumorigenesis. Catenins are intracellular proteins that link the cytoplasmic domains of the cadherins to the cytoskeletons to promote the biological functions of these CAMs. In this study, we compared the expression of E-, N-, and P-cadherins and alpha-, beta-, and gamma-catenins in the uterine leiomyomas and the counterparts of normal myometrium of the same patients by using semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR) and Western blot analysis. Of these, E-cadherin (E-cad) was not detected in both uterine leiomyomas and myometrium, P-cadherin (P-cad) was similarly expressed in these two tissues, but N-cadherin (N-cad) mRNA and protein expression levels in uterine leiomyomas were significantly greater than those observed in the myometrium. Catenins were not differentially expressed in uterine myometrium and leiomyomas. The overexpression of N-cad in uterine leiomyomas suggests that this CAM may play a central role in the development of uterine leiomyomas. |
| 關聯: | OTOLOGY & NEUROTOLOGY 24(1):29-32 |
| 顯示於類別: | [台中附設醫院] 期刊論文
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