Detection of recurrent nasopharyngeal carcinomas with thallium-201 single-photon emission computied tomography in patients with indeterminate magnetic resonance imaging findings after radiotherapy

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Title:	Detection of recurrent nasopharyngeal carcinomas with thallium-201 single-photon emission computied tomography in patients with indeterminate magnetic resonance imaging findings after radiotherapy
Authors:	Tai, CJ;Liang, JA;Yang, SN;Tsai, MH;Lin, CC;Kao, CH
Contributors:	附設醫院耳鼻喉部;China Med Coll Hosp, Dept Otolaryngol, Taichung 404, Taiwan;China Med Coll Hosp, Dept Radiat Therapy & Oncol, Taichung, Taiwan;China Med Coll Hosp, Dept Family Med, Taichung, Taiwan;China Med Coll Hosp, Dept Nucl Med, Taichung, Taiwan
Date:	2003
Issue Date:	2010-09-24 14:24:22 (UTC+8)
Publisher:	JOHN WILEY & SONS INC
Abstract:	Purpose Genetic factors are known to play a role in the aetiology of glaucoma, and in particular the role of the immune system is highly suspected. In this study, we evaluated the association between tumour necrosis factor alpha -308 (TNF alpha -308) and primary open-angle glaucoma (POAG). Methods A total of sixty POAG patients and 103 healthy volunteers as control group were enrolled in this case-controlled study. Furthermore, we used polymerase chain reaction based analysis to resolve the TNF alpha -308 polymorphism. Statistical analysis for the relative risk of TNF alpha -308 polymorphism was compared by the chi(2) test. Results There were significant differences in the distribution of the polymorphism between the POAG patients and the control subjects (P = 0.00016; P < 0.05) and it was found that the A(-308) allele occurred more frequently in POAG patients (odds ratio: 2.72; 95% confidence interval: 1.66-4.45). Conclusion The results of our study concluded that the distribution of TNF alpha -308 was significantly higher in the POAG patients than in the control group. Therefore, the A(-308) allele appears to be associated with POAG and, therefore, could be used as a genetic marker for disease mapping. POAG is a complex disease, and a single gene could not be responsible. Understanding the role of genetic polymorphisms, like TNF alpha, could be a prediction of the disease and useful for developing new treatments for POAG.
Relation:	HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK 25(3):227-231
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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