HUMAN SKIN MITOCHONDRIAL-DNA DELETIONS ASSOCIATED WITH LIGHT EXPOSURE

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Title:	HUMAN SKIN MITOCHONDRIAL-DNA DELETIONS ASSOCIATED WITH LIGHT EXPOSURE
Authors:	PANG, CY;LEE, HC;YANG, JH;WEI, YH
Contributors:	附設醫院皮膚科;CHINA MED COLL HOSP,DEPT DERMATOL,TAICHUNG,TAIWAN;NATL YANG MING MED COLL,INST CLIN MED,DEPT & INST BIOCHEM,TAIPEI,TAIWAN
Date:	1994
Issue Date:	2010-09-24 14:23:44 (UTC+8)
Publisher:	ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS
Abstract:	As part of our continuing search for potential anticancer drug candidates in the 2-phenyl-4-quinolone series, we have synthesized a series of 6,7-methylenedioxy-substituted and unsubstituted 2-phenyl-4-quinolones, as well as related compounds. Their in vitro inhibition of human tumor cell lines and tubulin polymerization is reported. In general, a good correlation was found between cytotoxicity and inhibition of tubulin polymerization. Compounds 7, 9, 13, 16, 22, 23, 36, and 37 showed potent inhibitory effects in both assays. AH rigid analogs (47-49) and trimethoxy-substituted compounds showed little or no activity. Substitution at the 4'-position also resulted in compounds with little or no activity, except for hydroxyl or methyl groups at this position. Further investigation is underway to determine if substitution at the 3'-position will result in compounds with increased activity.
Relation:	ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 312(2):534-538
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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