中國醫藥大學機構典藏 China Medical University Repository, Taiwan:Item 310903500/29140
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    题名: Spontaneous hemopneumothorax revisited: Clinical approach and systemic review of the literature
    作者: Hsu, NY;Shih, CS;Hsu, CP;Chen, PR
    贡献者: 附設醫院外科部胸腔外科;China Med Univ Hosp, Dept Surg, Div Chest Surg, Taichung 404, Taiwan;Natl Yang Ming Univ, Sch Med, Taichung Vet Gen Hosp, Dept Surg,Div Thorac Surg, Taipei 112, Taiwan
    日期: 2005
    上传时间: 2010-09-24 14:23:36 (UTC+8)
    出版者: ELSEVIER SCIENCE INC
    摘要: The pathophysiology of Tourette syndrome may involve the dopamine system. Dysfunction of the dopamine receptor D2 gene leads to many neuropsychiatric disorders. The objective of this study is to test the hypothesis that the dopamine receptor D2 gene may play a role in Tourette syndrome. A total of 151 children with Tourette syndrome and 183 normal control subjects were included in the study. Polymerase chain reaction was used to identify the Taq I DRD2 and DRD2 (H313H) polymorphisms of the dopamine receptor D2 gene. The genotype proportions of Tail I DRD2 and DRD2 (H313H) polymorphisms in the two groups were significantly different (P < 0.01 for both). The odds ratio for developing Tourette syndrome in individuals with the Taq I DRD2 A1 homozygote was 2.253 (95% confidence interval, 1.124-4.517) compared with individuals with the Taq I DRD2 A2 homozygote. The odds ratio for developing Tourette syndrome in individuals with the DRD2 (H313H) C homozygote was 2.96 (95% confidence interval, 1.398-6.269) compared with individuals with DRD2 (H313H) T homozygote. This study has demonstrated an association between the dopamine receptor D2 gene and Tourette syndrome. These data suggest that the dopamine receptor D2 gene or a closely linked gene might be one of the susceptibility factors for Tourette syndrome. (c) 2005 by Elsevier Inc. All rights reserved.
    關聯: ANNALS OF THORACIC SURGERY 80(5):1859-1863
    显示于类别:[台中附設醫院] 期刊論文

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