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| 題名: | Confirmation of extended-spectrum beta-lactamase-producing Serratia marcescens: preliminary report from Taiwan |
| 作者: | Yu, WL;Wu, LT;Pfaller, MA;Winokur, PL;Jones, RN |
| 貢獻者: | 附設醫院內科部感染科;China Med Coll Hosp, Dept Med, Infect Dis Sect, Taichung, Taiwan;China Med Coll, Inst Med Sci, Dept Microbiol, Taichung, Taiwan;Univ Iowa, Coll Med, Iowa City, IA USA;JONES Grp, JMI Lab, N Liberty, IA USA |
| 日期: | 2003 |
| 上傳時間: | 2010-09-24 14:21:28 (UTC+8) |
| 出版者: | ELSEVIER SCIENCE INC |
| 摘要: | The degradation of thirteen flavonoid aglycones-wogonin, diosmetin, hesperetin, baicalein, morin, genistein, daidzein, quercetin, naringenin, luteolin, kaempferol, apigenin and neophellamuretin-were investigated in rabbit, rat and human fecal flora suspensions as well as in artificial intestinal juice, using high performance liquid chromatography. Separation were performed with a Cosmosil 5C(18)-AR II column by isocratic and gradient elution with 0.1% (v/v) phosphoric acid-acetonitrile as a mobile phase, and detected at 254 nm. The flow rate was 1.0 ml/min. 5,7-Dimethoxycoumarin was used as the internal standard. The result indicated that all flavonoid aglycones except baicalein, diosmetin and quercetin were quite stable in artificial intestinal juice, whereas all were degraded in rabbit, rat and human feces suspension. In rabbit feces, wogonin, diosmetin and hesperetin were less degraded, whereas neophellamuretin, apigenin, kaempferol, luteolin, and naringenin were the most extensively degraded. In rat feces, wogonin and diosmetin were least degraded, whereas kaempferol, quercetin, genistein, luteolin, naringenin and neophellamuretin were extensively degraded. As in human feces, wogonin, daidzein and diosmetin were less degraded, whereas morin, genistein, baicalein, and quercetin were extensively degraded. In conclusion, wogonin and diosmetin were among the less degraded ones for all three feces tested. The presence of a methoxy group on the A or B ring of the flavonoid seems to protect the structure from bacterial degradation. |
| 關聯: | DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE 45(4):221-224 |
| 顯示於類別: | [台中附設醫院] 期刊論文
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