Changes in the clinical and laboratory features of lupus patients after the big earthquake in Taiwan

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Title:	Changes in the clinical and laboratory features of lupus patients after the big earthquake in Taiwan
Authors:	Chou, CT;Hwang, CM
Contributors:	附設醫院內科部風濕免疫科;Vet Gen Hosp, Div Allergy Immunol Rheumatol, Taipei, Taiwan;China Med Coll Hosp, Div Allergy Immunol Rheumatol, Taichung, Taiwan
Date:	2002
Issue Date:	2010-09-24 14:20:40 (UTC+8)
Publisher:	ARNOLD, HODDER HEADLINE PLC
Abstract:	To test this hypothesis, salivary function was measured by quantitative salivary scintigraphy in noninsulin-dependent diabetes mellitus (NIDDM) patients, as well as in age- and sex-matched controls for comparison. Seventy-two patients with NIDDM history of over 10 years and 36 healthy age- and sex-matched controls were enrolled in the study. All of the 72 NIDDM patients had good blood sugar control. None presented with autonomic neuropathy, These 72 NIDDM patients were separated into two subgroups. Group 1: 36 patients with xerostomia and Group 2: 36 patients without xerostomia. After intravenous injection of 5mCi Tc-99m pertechnetate, sequential images at 1 min/frame were acquired for 30 min. The 1st and 15th minute uptake ratios (UR) were calculated from the tracer uptakes in the four major salivary glands over the background regions of interest. Saliva excretion was stimulated by one tablet of 200 mg ascorbic acid given orally 15-min postinjection. of the tracer. Then, the maximal excretion ratios (ER) of the four major salivary glands after sialagogue stimulation were calculated. Significantly poorer salivary function was found, represented by significantly decreased UR and ER values, in 36 NIDDM patients with xerostomia, when compared with 36 NIDDM patients without xerostomia and 36 healthy controls, via objective and quantitative salivary scintigraphy. It has been speculated that impaired salivary function contributes to NIDDM with xerostomia. However, further studies with a larger series of NIDDM patients are necessary to confirm our findings. (C) 2002 Elsevier Science Inc. All rights reserved.
Relation:	LUPUS 11(2):109-113
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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