Alteration of autoantibodies against p53 in Taiwanese lung cancer patients undergoing chemotherapy

CMUR > China Medical University Hospital > Jurnal articles > Item 310903500/29063

Please use this identifier to cite or link to this item: http://ir.cmu.edu.tw/ir/handle/310903500/29063

Title:	Alteration of autoantibodies against p53 in Taiwanese lung cancer patients undergoing chemotherapy
Authors:	Lee, YL;Shi, CM;Chiou, HL;Shiau, MY;Chang, GC;Chang, YH
Contributors:	附設醫院內科部呼吸治療科;Chung Shan Med Univ, Sch Med Technol, Taichung, Taiwan;Chung Shan Med Univ, Inst Biochem, Taichung, Taiwan;China Med Univ Hosp, Dept Internal Med, Div Pulm & Crit Care Med, Taichung, Taiwan;Chung Shan Med Univ, Inst Med, Taichung, Taiwan;Hung Kuang Univ, Taichung 433, Taiwan;Taichung Vet Gen Hosp, Dept Internal Med, Div Chest Med, Taichung, Taiwan
Date:	2004
Issue Date:	2010-09-24 14:20:18 (UTC+8)
Publisher:	ELSEVIER SCIENCE BV
Abstract:	Kawasaki disease is an acute febrile illness typically elicited by vasculitis and occurring in young children. We investigated the polymorphism of the angiotensin-1 converting enzyme (ACE) gene in children with Kawasaki disease and also in age-matched controls. A total of 107 children, with a mean age at diagnosis of 1.71 +/- 1.48 years, who suffered from Kawasaki disease and who were treated with aspirin as well as intravenous immunoglobulin were enrolled in this study. Control subjects consisted of 107 children, with a mean age of 1.84 +/- 1.20 years. The polymorphisms of the ACE gene, including I/D, A-240T, and G2350A, were examined using a polymerase chain reaction method for Kawasaki disease patients and also for control subjects. We noted a significant difference in the distribution of the ACE gene I/D genotype between Kawasaki disease and control groups. The ACE gene G2350A polymorphism and associated allelic frequencies demonstrated an association with Kawasaki disease. Our results revealed no evidence of any association between the ACE gene polymorphism and the frequency of coronary artery aneurysm associated with Kawasaki disease, although our results do support a role for the I/D and G2350A polymorphism of the ACE gene in determining the risk of Kawasaki disease in the population of Taiwan.
Relation:	CLINICA CHIMICA ACTA 349(1月2日):87-96
Appears in Collections:	[China Medical University Hospital] Jurnal articles

Files in This Item:

There are no files associated with this item.

Loading...