Association between transforming growth factor-beta 1 gene C-509T and T869C polymorphisms and rheumatic heart disease

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Title:	Association between transforming growth factor-beta 1 gene C-509T and T869C polymorphisms and rheumatic heart disease
Authors:	Chou, HT;Chen, CH;Tsai, CH;Tsai, FJ
Contributors:	附設醫院內科部心臟科;China Med Univ Hosp, Dept Med, Div Cardiol, Taichung 404, Taiwan;Taichung Healthcare & Management Univ, Taichung, Taiwan;China Med Univ Hosp, Dept Pediat Med Res & Med Genet, Taichung, Taiwan;China Med Univ, Coll Chinese Med, Taichung, Taiwan;Acad Sinica, Inst Biomed Sci, Taipei, Taiwan
Date:	2004
Issue Date:	2010-09-24 14:19:38 (UTC+8)
Publisher:	MOSBY, INC
Abstract:	The aim of this study was to determine how polymorphisms of transporters associated with transporter and antigen processing 1 (TAP1) alleles contributed to the pathogenesis of systemic lupus erythematosus (SLE) in Taiwan. We collected 88 patients with SLE and 104 healthy people for the control group. The polymorphisms were detected as a result of polymerase chain reaction (PCR)-based restriction analysis. Associations between SLE and TAP1 polymorphisms were evaluated. The results revealed no significant differences between the healthy individuals and SLE patients with TAP1-1 (Dpn II) and TAP1-2 (AccI) polymorphisms (P = 0. 10 and 0.36, respectively). However, the G alleles of TAP1-1 and TAP1-2 were significantly more common than the A alleles in serositis of SLE patients (chi(2) = 11.16 and P = 0.004, chi(2) = 8.10 and P = 0.02, respectively).
Relation:	AMERICAN HEART JOURNAL 148(1):181-186
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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