Association between angiotensin I-converting enzyme gene insertion/deletion polymorphism and risk of rheumatic heart disease

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Title:	Association between angiotensin I-converting enzyme gene insertion/deletion polymorphism and risk of rheumatic heart disease
Authors:	Chou, HT;Tsai, CH;Tsai, FJ
Contributors:	附設醫院內科部心臟科;China Med Univ Hosp, Dept Med, Div Cardiol, Taichung 404, Taiwan;Taichung Healtchcare & Management Univ, Taichung, Taiwan;China Med Univ Hosp, Dept Pediat Med Res & Med Genet, Taichung 404, Taiwan;China Med Univ, Coll Chinese Med, Taichung, Taiwan
Date:	2004
Issue Date:	2010-09-24 14:19:31 (UTC+8)
Publisher:	JAPAN HEART JOURNAL, SECOND DEPT OF INTERNAL MED
Abstract:	Objective: Androgen receptor (AR) was detected in leiomyoma. AR gene has a polymorphic microsatellite encoding cytosine, adenine, and guanine (CAG) repeats. We aimed to investigate the association between the AR gene CAG repeats and leiomyoma. Methods: Women were divided into two groups: (1) leiomyoma (n = 159); (2) non-leiomyoma groups (n = 129). Their CAG repeats were detected by polymerase chain reaction. The CAG repeats ranged in length from 168 bp (9 CAG repeats, genotype A) to 234 bp (31 CAG repeats, genotype W). Distributions of CAG repeats in both groups were compared. Results: Genotype proportions of different CAG repeats for AR gene in both groups were significantly different. The genotype S (27 CAG repeats) is associated with higher susceptibility of leiomyoma. Distribution of CAG repeats in both groups appeared mono-peak distributions. Percentages of genotypes K-S (19-27 CAG repeats) in leiomyoma and non-leiomyoma groups were: (1) 5, 11, 19.5, 10.4, 12.9, 8.8, 7.5, 5.7, 4.4%; (2) 5.4, 14.3, 16.7, 12.8, 12.4, 5.8, 9.3, 7, 1.2%. Conclusions: AR trinucleotide polymorphism is associated with leiomyoma susceptibility. The 27 CAG repeats is related with higher risk of leiomyoma.
Relation:	JAPANESE HEART JOURNAL 45(6):949-957
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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