Association of the nicotinic receptor beta 2 subunit and febrile seizures

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题名:	Association of the nicotinic receptor beta 2 subunit and febrile seizures
作者:	彭慶添(Ching-Tien Peng);周宜卿(I-Ching Chou);李佳霙(Chia-Ing Li);許妤安(Yu-An Hsu);蔡長海(Chang-Hai Tsai);蔡輔仁(Fuu-Jen Tsai)
贡献者:	中醫學院中醫學系學士班中醫內科學科;中國附醫兒童醫學中心小兒血液腫瘤科
关键词:	Introduction;Patients and methods;Results;Discussion;References
日期:	2004
上传时间:	2009-08-20 17:57:33 (UTC+8)
摘要:	The nicotinic acetylcholine receptors are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. Mutations in neuronal nicotinic acetylcholine receptor beta 2 subunit have been associated with autosomal dominant nocturnal frontal lobe epilepsies. A major challenge is to establish whether the monogenic epilepsy gene also contributes to the common epilepsies. Because febrile seizures represent the majority of childhood seizures, and a genetic predisposition, we investigated the possibility that the nicotinic acetylcholine receptor beta 2 subunit might be involved in the etiology of febrile seizures. Children were divided into two groups: those with febrile seizures (group 1; N = 104) and control patients (group 2; N = 83). Polymerase chain reaction was used to identify the G/C and T/C polymorphisms of the nicotinic acetylcholine receptor beta 2 subunit gene, which is mapped on chromosome 1. Genotypes and allelic frequencies for nicotinic acetylcholine receptor beta 2 subunit gene polymorphisms in both groups were compared. The results indicated that genotypes and allelic frequencies in both groups were not significantly different. These data suggest that nicotinic acetylcholine receptor beta 2 subunit polymorphisms are not a useful marker for prediction of the susceptibility to febrile seizures.
關聯:	PEDIATRIC NEUROLOGY30(3):186~189
显示于类别:	[中醫學系暨碩博班] 期刊論文

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