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資料載入中.....
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請使用永久網址來引用或連結此文件:
http://ir.cmu.edu.tw/ir/handle/310903500/29014
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| 題名: | The physiological mechanisms of 2 Hz electroacupuncture: A study using blink and H reflex |
| 作者: | Hsieh, CL;Wu, CHW;Lin, JG;Chiu, CC;Chen, M;Hsieh, CT |
| 貢獻者: | 附設醫院內科部;China Med Coll Hosp, Internal Med Chinese Med Dept, Taichung, Taiwan |
| 日期: | 2002 |
| 上傳時間: | 2010-09-24 14:18:43 (UTC+8) |
| 出版者: | WORLD SCIENTIFIC PUBL CO PTE LTD |
| 摘要: | The association between metabolic polymorphisms and cigarette smoking-induced cancers has been documented. However, the role of DNA repair polymorphism in carcinogenesis is less clear. To investigate if the polymorphisms of metabolic traits and DNA repair modulate smoking-related DNA damage, we used sister chromatid exchange (SCE) as a marker of genetic damage to explore the relationship of microsomal epoxide hydrolase (mEH), glutathione S-transferase M1 (GSTM1), and X-ray cross-complementing group 1 (XRCC1) and cigarette smoking-induced SCE. Sixty-one workers without significant exposure to mutagens were recruited. Questionnaires were completed to obtain detailed occupational, smoking, and medical histories. SCE frequency in peripheral lymphocytes was determined using a standard cytogenetic assay and GSTM1, mEH (exons 3 and 4), XRCC1 (codon 399) genotypes were determined using polymerase chain reaction-restriction fragment length polymorphism (PCR/PFLP). Smokers had higher SCE frequency than non-smokers (8.4 versus 7.1, P < 0.05). Among workers who had smoked equal to or greater than 10 cigarettes each day, those with XRCC1 Arg/Gln + Gln/Gln had higher SCE frequency than those with XRCC1 Arg/Arg after adjusting for potential confounders (9.0 versus 7.9, P < 0.05). The interaction of XRCC1 and cigarettes smoked per day on SCE frequency was also observed (P = 0.02). There was no significant interaction between cigarettes smoked per day with GSTM1 and mEH on SCE frequency. Our results support previous epidemiological studies that XRCC1 may play a role in cigarette smoking-induced lung cancer. (C) 2002 Elsevier Science B.V. All rights reserved. |
| 關聯: | AMERICAN JOURNAL OF CHINESE MEDICINE 30(2月3日):369-378 |
| 顯示於類別: | [台中附設醫院] 期刊論文
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