Inhibitory actions of berberine on growth and arylamine N-acetyltransferase activity in strains of Helicobacter pylori from peptic ulcer patients

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Title:	Inhibitory actions of berberine on growth and arylamine N-acetyltransferase activity in strains of Helicobacter pylori from peptic ulcer patients
Authors:	Chung, JG;Wu, LT;Chang, SH;Lo, HH;Hsieh, SE;Li, YC;Hung, CF
Contributors:	附設醫院內科部;China Med Coll, Dept Med, Taichung 400, Taiwan;Chung Tai Inst Hlth Sci & Technol, Dept Med Technol, Taichung, Taiwan;Taipei Municipal Jen Ai Hosp, Dept Surg, Taichung, Taiwan
Date:	1999
Issue Date:	2010-09-24 14:18:27 (UTC+8)
Publisher:	TAYLOR & FRANCIS LTD
Abstract:	This study examined the effects of various polyunsaturated fatty acid (PUFA, P)/saturated fatty acid (SFA, S) ratio versus PUFA + monounsaturated fatty acid (MUFA, M)/SFA ratio on lipid metabolism. The P/S ratio of dietary fat was fixed at a certain level (0.5, 1, 2, or 4, respectively) for each of four pairs of rat groups respectively, and then the P + M/S ratio was changed for the four pairs of rat groups. When the P/S ratio was fixed at 0.5, 1, 2, or 4, the plasma total cholesterol, LDL-cholesterol (C), and HDL-C levels did not show any significant difference in each pair of groups with different P + M/S ratios. However, when the P/S ratio was fixed at 1.0, the higher P + M/S ratio of 5.7 (M/S = 4.7, P/M = 0.2) resulted in significantly higher plasma total triacylglycerol (TAG), VLDL-TAG, VLDL-C, and VLDL-phospholipid (PL) than the lower P + M/S ratio of 1.4 (M/S = 0.4, P/M = 2.4). Whereas when SFA was fixed at a similar level, it therefore had approximately the same P + M/S ratio(5.3, 5.6, 5.7), and by increasing the P/S ratio from 1, 2 to 4 (70.4, 52.7 and 23.2% of the total fatty acids as MUFA respectively), the plasma VLDL-C, VLDL-TAG, and VLDL-PL concentrations decreased progressively. When PUFA or MUFA was kept on a similar level (14.9 or 53% respectively), the higher P + M/S ratio (5.7 or 5.3, respectively) resulted in significantly greater accumulation of liver cholesterol than the lower P + M/S ratio of 2.2. When the P/S ratio was fixed at 1 or 4, the diet of higher P + M/S ratio in a pair of the groups also resulted in greater accumulation of liver cholesterol. The results of the study suggests that if the P + M/S ratio was below 3, the change in the P/S ratios (0.5, 1 or 2) did not affect the levels of plasma total and lipoprotein cholesterol and TAG. Increases in the plasma VLDL-C and VLDL-TAG were related to increased MUFA content in the diet. And high MUFA content resulted in greater accumulation of liver cholesterol. It seems that the prerequisites for keeping low plasma and liver cholesterol are (a) low M/S ratio and (b) high PIM ratio and (c) P + M/S ratio not to exceed 3. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.
Relation:	INTERNATIONAL JOURNAL OF TOXICOLOGY 18(1):35-40
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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