Microglia, apoptosis and interleukin-1 beta expression in the effect of Sophora japonica L. on cerebral infarct induced by ischemia-reperfusion in rats

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Title:	Microglia, apoptosis and interleukin-1 beta expression in the effect of Sophora japonica L. on cerebral infarct induced by ischemia-reperfusion in rats
Authors:	Lao, CJ;Lin, JG;Kuo, JS;Chao, PDL;Cheng, CY;Tang, NY;Hsieh, CL
Contributors:	附設醫院中醫部;China Med Univ Hosp, Dept Chinese Med, Taichung, Taiwan;Tzu Chi Univ, Coll Med, Inst Med Sci, Hualien, Taiwan;China Med Univ, Grad Inst Chinese Med Sci, Taichung, Taiwan;China Med Univ, Sch Chinese Med, Taichung, Taiwan;China Med Univ, Coll Chinese Med, Grad Inst Integrat Chinese & Western Med, Taichung, Taiwan;China Med Univ, Coll Pharm, Dept Pharm, Taichung, Taiwan
Date:	2005
Issue Date:	2010-09-24 14:17:54 (UTC+8)
Publisher:	WORLD SCIENTIFIC PUBL CO PTE LTD
Abstract:	OBJECTIVE: To evaluate whether a short course of prophylactic antibiotics is as efficacious as a longer course in laparoscopically assisted vaginal hysterectomy (LAVH). STUDY DESIGN: A total Of 156 patients who underwent LAVH were included in the study; 82 received a long course of combined prophylactic antibiotics, and 74 received a short course, administered for < 24 hours during the perioperative period. The subjects were randomly assigned using a computer-generated schedule. Data regarding resource consumption were collected from the hospital's electronic database. Patient characteristics and medical care process data were collected from the patient charts. Student's t test was used to determine the statistical significance of the differences between continuous variables in the 2 groups of patients. The chi(2) test was used to measure the statistical significance of differences between nominal variables in the 2 groups. RESULTS: The short course significantly influenced the number of injected vials of antibiotics, the antibiotic fee and the total admission fee. The average total admission fee decreased by 2.3% (p = 0.034), and the average antibiotic fee dropped by 68.4% (p < 0.01). The average injected vials of cephalothin decreased by 4.3, and the vials of gentamycin decreased by 3.3 (p < 0.01). As for the rate of operative site infection and urinary tract infection during hospitalization and within 7 days of discharge, no statistical differences were found between the 2 groups (p = 0.735; p = 0.917). CONCLUSION: This pilot study revealed that a short course of prophylactic antibiotics was as efficacious as a longer course in preventing postoperative infection. It was also cost-effective.
Relation:	AMERICAN JOURNAL OF CHINESE MEDICINE 33(3):425-438
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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