Valacyclovir treatment ameliorates the persistently increased pentylenetetrazol-induced seizure susceptibility in mice with herpes simplex virus type 1 infection

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 台中附設醫院 > 期刊論文 > Item 310903500/28984

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题名:	Valacyclovir treatment ameliorates the persistently increased pentylenetetrazol-induced seizure susceptibility in mice with herpes simplex virus type 1 infection
作者:	Wu, HM;Liang, YC;Chen, SH;Huang, CC;Chen, SH;Tsai, JJ;Hsieh, CL;Hsu, KS
贡献者:	附設醫院中醫部;Natl Cheng Kung Univ, Coll Med, Dept Pharmacol, Tainan 701, Taiwan;Natl Cheng Kung Univ, Coll Med, Inst Basic Med Sci, Tainan 701, Taiwan;Kuang Tein Gen Hosp, Dept Neurol, Taichung, Taiwan;Natl Cheng Kung Univ, Coll Med, Dept Microbiol & Immunol, Tainan 70101, Taiwan;Natl Cheng Kung Univ, Coll Med, Dept Neurol, Tainan 70101, Taiwan;China Med Univ Hosp, Chinese Med Dept, Internal Med Sect, Taichung, Taiwan;China Med Univ, Inst Integrat Chinese & Western Med, Taichung, Taiwan
日期:	2004
上传时间:	2010-09-24 14:17:51 (UTC+8)
出版者:	ACADEMIC PRESS INC ELSEVIER SCIENCE
摘要:	Methylprednisolone pulse therapy (MPT) was introduced to avoid life-threatening complications in patients with systemic lupus erythematosus (SLE) with brain manifestations; however, the efficacy of MPT in SLE patients with brain involvement is still uncertain and needs to be objectively evaluated. We enrolled 15 female SLE patients with neuropsychiatric manifestations in this study. All patients had normal brain MRI and abnormal brain HMPAO-SPECT findings. Followup HMPAO-SPECT studies were conducted 2 weeks after MPT. Serum levels of anticardiolipin antibodies (ACA) and anti-ribosomal P antibodies (anti-P) were measured before and after MPT. Before MPT, 7 patients were positive for ACA and 7 patients were positive for anti-P. After MPT, none of the 15 patients demonstrated positive serologic findings or neuropsychiatric manifestations. Based on the follow up brain HMPAO-SPECT images following MPT, 13 patients showed disappearance of the perfusion defects and 2 patients showed partial recovery of rCBF. Brain HMPAO-SPECT imaging is a logical and objective tool for measuring the effects of MPT in SLE patients with brain involvement by determining of changes in rCBF.
關聯:	EXPERIMENTAL NEUROLOGY 189(1):66-77
显示于类别:	[台中附設醫院] 期刊論文

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