Effect of electroacupuncture and transcutaneous electrical nerve stimulation at Hegu (LI.4) acupuncture point on the cutaneous reflex

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Title:	Effect of electroacupuncture and transcutaneous electrical nerve stimulation at Hegu (LI.4) acupuncture point on the cutaneous reflex
Authors:	Chang, QY;Lin, JG;Hsieh, CL
Contributors:	附設醫院中醫部;China Med Coll Hosp, Chinese Med Dept, Internal Med Sect, Taichung, Taiwan;China Med Coll, Inst Chinese Med Sci, Taichung, Taiwan;Taichung Hosp, Dept Family Med, Taichung, Taiwan;China Med Coll, Acupuncture Res Ctr, Taichung, Taiwan;China Med Coll Hosp, Inst Integrat Chinese & Western Med, Taichung, Taiwan
Date:	2002
Issue Date:	2010-09-24 14:17:49 (UTC+8)
Publisher:	COGNIZANT COMMUNICATION CORP
Abstract:	Estrogen plays a role in the pathogenesis of leiomyoma. The CYP17 gene codes for the cytochrome P450c17alpha enzyme, which is involved in the biosynthesis of estrogen. Our aim was to investigate if CYP17 polymorphism could be a useful marker to predict the susceptibility to leiomyoma. Our sample of female subjects was divided into two groups: (1) with leiomyoma (n = 159); (2) without leiomyoma (n = 128). A 169-bp fragment encompassing the A1/A2 polymorphic site of the CYP17 gene was amplified by polymerase chain reaction (PCR), restricted by enzyme MspA11 and electrophored on agarose gel. Genotypes and allelic frequencies for this polymorphism in both groups were compared. There was no significant difference between the two groups regarding the distribution of the CYP17 gene polymorphism frequencies. The A1 homozygote/heterozygote/A2 homozygote proportions for CYP17 in both groups were: (1) 17.0/46.5/36.5%, and (2) 17.2/45.3/37.5%. The proportions for alleles A1 and A2 were also comparable in the two groups. A1 and A2 allele frequencies were: 7% (40.3/59) in group 1, and 2% (39.8/60) in group 2. No significant association was observed between the risk of leiomyoma and polymorphisms of the CYP17 gene. So, CYP17 gene polymorphism does not appear to be a useful marker for the prediction of leiomyoma susceptibility.
Relation:	ACUPUNCTURE & ELECTRO-THERAPEUTICS RESEARCH 27(3月4日):191-202
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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