COMBINED EFFECTS OF GINSENG AND RADIOTHERAPY ON EXPERIMENTAL LIVER-CANCER

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Title:	COMBINED EFFECTS OF GINSENG AND RADIOTHERAPY ON EXPERIMENTAL LIVER-CANCER
Authors:	YOU, JS;HAU, DM;CHEN, KT;HUANG, HF
Contributors:	附設醫院中醫部;NATL TSING HUA UNIV,INST RADIAT BIOL,HSINCHU 30043,TAIWAN;CHINA MED COLL HOSP,DEPT CHINESE MED,TAICHUNG 40421,TAIWAN
Date:	1995
Issue Date:	2010-09-24 14:17:41 (UTC+8)
Publisher:	JOHN WILEY & SONS LTD
Abstract:	Five isoflavanquinones have been isolated from the roots of Abrus precatorius L. (Leguminosae). Three of them are new and designated as abruquinones D, E, and F. The pharmacological activities of the isoflavanquinones have been evaluated. The results indicated that abruquinones A, B, and D exhibited remarkable inhibitory effects on the platelet aggregation. The IC50 of abruquinones A and B for the inhibition of the platelet aggregation induced by arachidonic acid (AA) and collagen were less than 5 mu g/ml, and of abruquinone D, was less than 10 mu g/ml for that induced by AA. On the other hand, abruquinones A, B, D, and F showed strong anti-inflammatory and antiallergic effects. The IC50 of abruquinones A, B, D, and F for the inhibition of superoxide formation were less than 0.3 mu g/ml, for the inhibition of the release of both beta-glucuronidase and lysozyme from rat neutrophils and the release of both beta-glucuronidase and histamine from mast cells were less than 1 mu g/ml.
Relation:	PHYTOTHERAPY RESEARCH 9(5):331-335
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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