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http://ir.cmu.edu.tw/ir/handle/310903500/28978
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| 題名: | Antifungal susceptibilities of clinical isolates of Candida species, Cryptococcus neoformans, and Aspergillus species from Taiwan: Surveillance of multicenter antimicrobial resistance in Taiwan program data from 2003 |
| 作者: | Hsueh, PR;Lau, YJ;Chuang, YC;Wan, JH;Huang, WK;Shyr, JM;Yan, JJ;Yu, KW;Wu, JJ;Ko, WC;Yang, YC;Liu, YC;Teng, LJ;Liu, CY;Luh, KT |
| 貢獻者: | 附設醫院;Natl Taiwan Univ, Natl Taiwan Univ Hosp, Coll Med, Dept Lab Med, Taipei 100, Taiwan;Natl Taiwan Univ, Natl Taiwan Univ Hosp, Coll Med, Dept Internal Med, Taipei 100, Taiwan;Taipei Vet Gen Hosp, Taipei, Taiwan;Taichung Vet Gen Hosp, Taichung, Taiwan;China Med Coll Hosp, Taichung, Taiwan;Chi Mei Med Ctr, Tainan, Taiwan;Natl Cheng Kung Univ Hosp, Tainan 70428, Taiwan;Kaohsiung Vet Gen Hosp, Kaohsiung, Taiwan |
| 日期: | 2005 |
| 上傳時間: | 2010-09-24 14:17:40 (UTC+8) |
| 出版者: | AMER SOC MICROBIOLOGY |
| 摘要: | General regulations and risk assessment regarding toxicants are single-compound oriented even though humans are exposed to multi-chemicals in the general environment. This study investigated the effects of different levels of N,N-dimethylformamide (DMF) and co-exposure levels of methyl ethyl ketone (MEK) and toluene (TOL) on two biomarkers of DMF exposure: nonmetabolized urinary (U-)DMF and the DMF metabolite urinary N-methylformamide (NMF). Thirty-five workers were selected from a two-stage field investigation strategy and were classified into four groups based on DMF exposure and co-exposure levels. Breathing-zone air concentrations of DMF, MEK, and TOL as well as dermal DMF exposure were determined. Post-shift U-DMF and U-NMF levels were determined for each individual. U-DMF concentrations were significantly higher in high-DMF groups than in low-DNIF groups, but U-NMF concentrations were significantly (P<0.05) lower in the high-DMF-high-coexposure group than in the high-DMF-low-co-exposure group; there were no significant differences between two low-DMF groups. The ratio of U-NMF to U-DMF showed the biotransformation from DMF to NMF was significantly suppressed at high co-exposure (P<0.001) for high-DMF exposure groups, possibly because of competitive inhibition of CYP2E1, the responsible enzyme involved. Due to the ubiquity of MEK/TOL in DMF-exposed occupational settings, the biological exposure index for occupational DNIF exposure should be re-evaluated at high co-exposure levels. (C) 2004 Elsevier Ireland Ltd. All rights reserved. |
| 關聯: | ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 49(2):512-517 |
| 顯示於類別: | [台中附設醫院] 期刊論文
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