Laboratory-based surveillance and molecular epidemiology of influenza virus in Taiwan

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 台中附設醫院 > 期刊論文 > Item 310903500/28977

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题名:	Laboratory-based surveillance and molecular epidemiology of influenza virus in Taiwan
作者:	Shih, SR;Chen, GW;Yang, CC;Yang, WZ;Liu, DP;Lin, JH;Chiu, SC;Chen, HY;Tsao, KC;Huang, CG;Huang, YL;Mok, CK;Chen, CJ;Lin, TY;Wang, JR;Kao, CL;Lin, KH;Chen, LK;Eng, HL;Liu, YC;Chen, PY;Lin, JS;Wang, JH;Lin, CW;Chan, YJ;Lu, JJ;Hsiung, CA;Chen, PJ;Su, IJ
贡献者:	附設醫院;NHRI, Div Clin Res, Taipei, Taiwan;Chang Gung Mem Hosp, Taipei 10591, Taiwan;Chang Gung Univ, Taipei, Taiwan;Ctr Dis Control & Prevent, Taipei, Taiwan;Natl Taiwan Univ Hosp, Taipei, Taiwan;Vet Gen Hosp, Taipei, Taiwan;Tri Serv Gen Hosp, Taipei, Taiwan;Natl Cheng Kung Univ, Tainan 70101, Taiwan;Kaohsiung Med Univ, Kaohsiung, Taiwan;Buddhist Tzu Chi Gen Hosp, Hualien, Taiwan;Changhua Christian Hosp, Changhua, Taiwan;China Med Univ Hosp, Taichung, Taiwan
日期:	2005
上传时间:	2010-09-24 14:17:38 (UTC+8)
出版者:	AMER SOC MICROBIOLOGY American Society for Microbiology
摘要:	Interleukin 4 (IL-4) stimulates and amplifies the inflammatory response, stimulates collagen synthesis in fibroblasts, promotes the progression to fibrosis and has been shown to inhibit the production of several inflammatory cytokines in the development of bronchopulmonary dysplasia (BPD) and airway hyperreactivity. We aimed to investigate whether IL-4 polymorphisms in ventilated preterm infants were associated with BPD. BPD was defined as infants who remained dependent on active respiratory support or oxygen supplementation at 36 weeks postconceptional age. A case-control study of 224 preterm infants ( ! 30 weeks) who had respiratory distress syndrome and needed intermittent mandatory ventilation (IMV) were undertaken between January 1999 and December 2003. The typing of each genetic polymorphism was performed by polymerase-chain-reaction-based restriction analysis. Genotype distribution and allelic frequencies were compared between ventilated preterm infants who developed BPD and those who did not and the duration of IMV. The demography of these ventilated BPD and non-BPD preterm infants was not different. We observed no significant differences in genotype distribution or allelic frequency of the IL-4 intron 3 or IL-4 promoter polymorphisms between ventilated preterm infants who developed BPD and who did not. There was no significant association of the genotype or allelic frequency of IL-4 polymorphism with duration of IMV. We conclude that neither IL-4 intron 3 nor the 590 promoter polymorphism is a useful marker for predicting the susceptibility to BPD in ventilated Taiwanese preterm infants. Copyright (C) 2005 S. Karger AG, Basel. A laboratory-based surveillance network of 11 clinical virological laboratories for influenza viruses was established in Taiwan under the coordination of the Center for Disease Control and Prevention (CDC), Taiwan. From October 2000 to March 2004, 3,244 influenza viruses were isolated, including 1,969 influenza A and 1,275 influenza B viruses. The influenza infections usually occurred frequently in winter in the northern hemisphere. However, the influenza seasonality in Taiwan was not clear during the four seasons under investigation. For example, the influenza A viruses peaked during the winters of 2001, 2002, and 2003. However, some isolated peaks were also found in the summer and fall (June to November) of 2001 and 2002. An unusual peak of influenza B also occurred in the summer of 2002 (June to August). Phylogenetic analysis shows that influenza A isolates from the same year were often grouped together. However, influenza B isolates from the year 2002 clustered into different groups, and the data indicate that both B/Victoria/2/87-like and B/Yamagata/16/88-like lineages of influenza B viruses were cocirculating. Sequence comparison of epidemic strains versus vaccine strains shows that many vaccine-like Taiwanese strains were circulating at least 2 years before the vaccine strains were introduced. No clear seasonality of influenza reports in Taiwan occurred in contrast to other more continental regions.
關聯:	JOURNAL OF CLINICAL MICROBIOLOGY 43(4):1651-1661
显示于类别:	[台中附設醫院] 期刊論文

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