Erk associates with and primes GSK-3 beta for its inactivation resulting in upregulation of beta-catenin

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Title:	Erk associates with and primes GSK-3 beta for its inactivation resulting in upregulation of beta-catenin
Authors:	Ding, QQ;Xia, WY;Liu, JC;Yang, JY;Lee, DF;Xia, JH;Bartholomeusz, G;Li, Y;Pan, Y;Li, Z;Bargou, RC;Qin, J;Lai, CC;Tsai, FJ;Tsai, CH;Hung, MC
Contributors:	附設醫院;Univ Texas, MD Anderson Canc Ctr, Dept Mol & Cellular Oncol, Houston, TX 77030 USA;Univ Texas, Grad Sch Biomed Sci, Houston, TX 77030 USA;Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Surg, Union Hosp, Wuhan 430022, Peoples R China;Humboldt Univ, Max Delbruck Ctr Mol Med, Robert Rossle Canc Clin, HELIOS Clin, D-13125 Berlin, Germany;Humboldt Univ, Max Delbruck Ctr Mol Med, Dept Hematol Oncol & Tumor Immunol, D-13125 Berlin, Germany;Baylor Coll Med, Dept Biochem, Houston, TX 77030 USA;China Med Univ Hosp, Taichung 404, Taiwan
Date:	2005
Issue Date:	2010-09-24 14:17:34 (UTC+8)
Publisher:	CELL PRESS
Abstract:	In the present study, role of guanosine-3',5'-cyclic monophosphate (cGMP) in the vasodilatation of tetramethylpyrazine (TMP), one of the active ingredients of the Chinese herb Chuang-xion, was investigated. We found that the TMP could decrease the vascular tone of isolated rat aorta precontracted with phenylephrine (10(-8) M) in a concentration-dependent manner from 10(-5) M to 10(-3) M. Also, the TMP-induced relaxation was reduced by 1H-(1,2,4)-oxadiazol-(4,3-a)-quinoxalin-1-one (ODQ) or methylene blue, the inhibitor of soluble guanylyl cyclase. Moreover, the vasodilative response to TMP was enhanced significantly in the presence of sildenafil, a well-known inhibitor of phosphodiestrase type 5 that is sensitive to cGMP. In addition, TMP could increase the cGMP level in the isolated aortic rings and TMP-induced vasodilatation was deleted by cGMP-dependent protein kinases (PKG) blockade. These results suggest that relaxation of rat aortic strip by TMP is induced in the cGMP-dependent manner. (c) 2005 Elsevier Inc. All rights reserved.
Relation:	MOLECULAR CELL 19(2):159-170
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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