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| 題名: | Factors affecting the mortality of pediatric fulminant hepatic failure in relation to hepatitis B virus infection |
| 作者: | Chan, PC;Chen, HL;Kong, MS;Huang, FC;Lee, HC;Lin, CC;Liu, CC;Lee, IH;Wu, TC;Wu, SF;Ni, YH;Hsu, HY;Chang, MH |
| 貢獻者: | 附設醫院;Natl Taiwan Univ Hosp, Dept Pediat, Taipei 100, Taiwan;Natl Taiwan Univ, Coll Med, Dept Primary Care Med, Taipei 10018, Taiwan;Chang Gung Childrens Hosp, Dept Pediat, Tao Yuan, Taiwan;Chang Gung Childrens Hosp, Dept Pediat, Kaohsiung, Taiwan;Mackay Mem Hosp, Dept Pediat, Taipei, Taiwan;Vet Gen Hosp, Dept Pediat, Taichung, Taiwan;Natl Cheng Kung Univ Hosp, Dept Pediat, Tainan 70428, Taiwan;Kaohsiung Med Univ Hosp, Dept Pediat, Kaohsiung, Taiwan;Tungs Taichung MetroHarbor Hosp, Dept Pediat, Taichung, Taiwan;Vet Gen Hosp, Dept Pediat, Taipei, Taiwan;China Med Coll Hosp, Taichung, Taiwan |
| 日期: | 2005 |
| 上傳時間: | 2010-09-24 14:17:32 (UTC+8) |
| 出版者: | BLACKWELL PUBLISHING |
| 摘要: | Purpose: We compared the in vitro potency and stability of a fixed combination of vancomycin and amikacin solution (VA solution) with amikacin or vancomycin solution. Methods: Solutions of 2% amikacin (20 mg/mL) and of 5% vancomycin (50 mg/mL) and VA solution (each 1 mL contained 20 mg of amikacin and 50 mg of vancomycin) were prepared from parenteral antibiotics by reconstituting them with sterile injection water and refrigerated (4 degrees C) in the dark. Triplicate 5-mL portions of each solution were tested before storage and 7 and 14 days after preparation for potency of antimicrobial activity by the disk diffusion method and for stability. Results: There were no significant differences in the diameter of zones of inhibition of VA solution compared with amikacin or vancomycin solution within a 2-week period. Visual inspection revealed that all solutions remained clear, colorless, and particle-free at 4 degrees C throughout the study period. For osmolarity, the VA solution was much higher than that of either amikacin or vancomycin solution at all tested times and more near the well-tolerated range of human eyes. There were no significant differences at days 0, 7, or 14 for either vancomycin, amikacin, or VA solution. For pH, the VA solution was higher than that of vancomycin solution (nearly equal to that of amikacin solution) at each time and more near the level of normal tear film. The pH did not differ significantly for either vancomycin, amikacin, or VA solution at all tested times. Conclusions: The vancomycin and amikacin ophthalmic solutions can be mixed together with the same potency and stable physical properties. It may be useful in the treatment of bacterial keratitis pending clinical trials to determine its effectiveness and safety. |
| 關聯: | JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 20(8):1223-1227 |
| 顯示於類別: | [台中附設醫院] 期刊論文
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