Role of zinc in subclinical hepatic encephalopathy: Comparison with somatosensory-evoked potentials

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Title:	Role of zinc in subclinical hepatic encephalopathy: Comparison with somatosensory-evoked potentials
Authors:	Yang, SS;Lai, YC;Chiang, TR;Chen, DF;Chen, DS
Contributors:	附設醫院;Cathay Gen Hosp, Liver Unit, Taipei 106, Taiwan;Cathay Gen Hosp, Div Neurol, Taipei 106, Taiwan;Cathay Gen Hosp, Nutr Support Serv, Taipei 106, Taiwan;Hepatitis Res Ctr, Taipei, Taiwan;Natl Taiwan Univ Hosp, Taipei, Taiwan;China Med Coll & Hosp, Fac Med, Taichung, Taiwan
Date:	2004
Issue Date:	2010-09-24 14:17:23 (UTC+8)
Publisher:	BLACKWELL PUBLISHING ASIA
Abstract:	CD30 is expressed on Hodgkin's Reed-Sternberg (H-RS) cells, the tumor cells in Hodgkin's disease. Increased levels of serum CD30 are observed in Hodgkin's disease patients and are a good marker for predicting a poor prognosis and a poor response to therapy. In this study, we addressed the effect of CD30 on T cells. We showed that CD30, either as a membranous protein on H-RS cells and Chinese hamster ovary cells or as a plate-bound chimeric protein, inhibited T-cell proliferation. Anti-CD3-stimulated T cells in the presence of CD30 failed to increase tritium uptake and failed to express CD25 and CD26 and to produce interleukin 2. The inhibition of T-cell proliferation was, however, reversed with addition of exogenous interleukin 2 or pretreatment of H-RS cells with anti-CD30. Inability of T cells to express CD25 and CD26 in cocultures with H-RS cells or a plate-bound CD30 chimeric protein is in accordance with the results of immunohistochemistry on disease-involved tissues. We conclude that H-RS cells are able to inhibit the proliferation and activation of T cells through CD30-related interaction. The outcome of CD30-related interaction is an ineffective antitumor immunity, which is clearly in favor of the growth and survival of the tumor cells.
Relation:	JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 19(4):375-379
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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