Epidemiology, clinical features and treatment outcome of Wilms' tumor in Taiwan: A report from Taiwan Pediatric Oncology Group

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Title:	Epidemiology, clinical features and treatment outcome of Wilms' tumor in Taiwan: A report from Taiwan Pediatric Oncology Group
Authors:	Hung, IJ;Chang, WH;Yang, CP;Jaing, TH;Liang, DC;Lin, KH;Lin, DT;Hsiao, CC;Hsieh, YL;Chen, JS;Chang, TT;Peng, CT;Shu, SG;Lin, MT;Chen, BW;Lin, KS
Contributors:	附設醫院;Chang Gung Mem Hosp, Chang Gung Childrens Hosp, Div Hematol Oncol, Taoyuan 33305, Taiwan;MacKay Mem Hosp, Dept Pediat, Taipei, Taiwan;ROC, Childhood Canc Fdn, Taipei, Taiwan;Natl Taiwan Univ Hosp, Taipei, Taiwan;Chang Gung Childrens Hosp, Kaohsiung, Taiwan;Natl Cheng Kung Univ Hosp, Tainan 70428, Taiwan;Vet Gen Hosp, Taipei, Taiwan;Kaohsiung Med Univ Hosp, Kaohsiung, Taiwan;China Med Coll Hosp, Taichung, Taiwan;Vet Gen Hosp, Taichung, Taiwan;Changhua Christian Hosp, Changhua, Taiwan;Koo Fdn Sun Yat Sen Canc Ctr, Taipei, Taiwan
Date:	2004
Issue Date:	2010-09-24 14:17:20 (UTC+8)
Publisher:	EXCERPTA MEDICA ASIA LTD
Abstract:	Background and Purpose: The Osteoporosis Self-Assessment Tool for Asians (OSTA) index, originally developed for use in postmenopausal Asian populations, is an inexpensive, simple tool based on age and body weight. Calcaneal quantitative ultrasound (QUS) is another simple and low-cost instrument used to prescreen osteoporotic subjects. This Study investigated the correlation between these 2 screening methods. Methods: OSTA indices were calculated in a total of 3456 women aged 40 to 95 years (mean, 59.5 +/- 11.7 years) selected from a national epidemiological survey of calcaneal QUS in Taiwan. Age was multiplied by -0.2 and body weight by 0.2. Both values were truncated to yield integers, which were then added together, and compared to the QUS results. Results: When the risk category was defined as OSTA index less than or equal to -1, and low QUS value as t-score less than or equal to -2.5, the sensitivity and the specificity of the index were 84.0% and 61.0%, respectively, and the area tinder the curve was 0.81. According to the OSTA research group's classification, the high-risk subgroup (index < -4) represented 10.7% of the women 40 years or older, the intermediate-risk subgroup (index -1 to -4) 35.0%, and the low-risk subgroup (index > -1) 54.3%. The prevalence of low QUS values was high among the high-risk category (48.5%), and significantly trended downwards among the moderate-and low-risk categories (21.1 % vs 4.4%). As the age of the population increased, there was an increasing false-negative rate (p < 0.001) when using OSTA > -1 to predict the normal QUS value. Conclusions: The OSTA index, a simple and free risk assessment tool, can be used to estimate the prevalence of low QUS values in Asian women and may help to increase awareness and prevention of low bone mineral density.
Relation:	JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION 103(2):104-111
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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