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| 題名: | Telithromycin- and fluoroquinolone-resistant Streptococcus pneumoniae in Taiwan with high prevalence of resistance to macrolides and beta-lactams: SMART program 2001 data |
| 作者: | Hsueh, PR;Teng, LJ;Wu, TL;Yang, D;Huang, WK;Shyr, JM;Chuang, YC;Wan, JH;Yan, JJ;Lu, JJ;Wu, JJ;Ko, WC;Chang, FY;Yan, YC;Lau, YJ;Liu, YC;Lee, CM;Leu, HS;Liu, CY;Luh, KT |
| 貢獻者: | 附設醫院;Natl Taiwan Univ, Coll Med, Natl Taiwan Univ Hosp, Dept Lab Med, Taipei 10018, Taiwan;Natl Taiwan Univ, Coll Med, Natl Taiwan Univ Hosp, Dept Internal Med, Taipei 10018, Taiwan;Chang Gung Mem Hosp, Taipei 10591, Taiwan;Mackay Mem Hosp, Taipei, Taiwan;Kaohsiung Vet Gen Hosp, Kaohsiung, Taiwan;Taichung Vet Gen Hosp, Taichung, Taiwan;Chi Mei Med Ctr, Tainan, Taiwan;China Med Coll Hosp, Taichung, Taiwan;Natl Cheng Kung Univ Hosp, Tainan 70428, Taiwan;Tri Serv Gen Hosp, Taipei, Taiwan;Taipei Vet Gen Hosp, Taipei, Taiwan |
| 日期: | 2003 |
| 上傳時間: | 2010-09-24 14:17:10 (UTC+8) |
| 出版者: | AMER SOC MICROBIOLOGY |
| 摘要: | This study evaluated the current status of antimicrobial resistance in clinical isolates of Streptococcus pyogenes in Taiwan as part of the SMART (Surveillance from Multicenter Antimicrobial Resistance in Taiwan) program. In 2001, 419 different isolates of S. pyogenes, including 275 from respiratory secretions, 87 from wound pus, and 31 from blood, were collected from nine hospitals in different parts of Taiwan. MICs of 23 antimicrobial agents were determined at a central location by the agar dilution method. All of the isolates were susceptible to penicillin (MIC at which 90% of the isolates were inhibited [MIC90], less than or equal to0.03 mug/ml), cefotaxime (MIC90, less than or equal to0.03 mug/ml), cefepime (MIC90, 0.06 mug/ml), meropenem (MIC90, less than or equal to0.03 mug/ml), moxifloxacin (MIC90, 0.25 mug/ml), vancomycin (MIC90, 0.5 mug/ml), and linezolid (MIC90, 1 mug/ml). Overall, 78% of isolates were not susceptible to erythromycin (54% were intermediate, and 24% were resistant), and 5% were not susceptible to clindamycin. Of the 101 erythromycin-resistant isolates, 80.2% exhibited the M phenotype (mefA gene positive), 18.9% exhibited the cMLS (constitutive resistance to macrolides-lincosamides-streptogramin B [MLS]) phenotype (ermB gene positive), and 1% exhibited the iMLS (inducible resistance to MLS) phenotype (ermB gene positive). Fluoroquinolones (sitafloxacin > moxifloxacin > ciprofloxacin = levofloxacin = gatifloxacin > gemifloxacin) demonstrated potent activity against nearly all of the isolates of S. pyogenes tested. Thirty-two isolates (8%) were not susceptible to quinupristin-dalfopristin. Seventeen percent of isolates had telithromycin MICs of greater than or equal to1 mug/ml, and all of these isolates exhibited erythroinycin MICs of greater than or equal to32 mug/ml. The high prevalence of resistance to telithromycin (which is not available in Taiwan) limits its potential use in the treatment of S. pyogenes infections, particularly in areas with high rates of macrolide resistance. |
| 關聯: | ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 47(7):2145-2151 |
| 顯示於類別: | [台中附設醫院] 期刊論文
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