Effect of San-Ao-Tang on immediate and late airway response and leukocyte infiltration in asthmatic guinea pigs

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 台中附設醫院 > 期刊論文 > Item 310903500/28952

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題名:	Effect of San-Ao-Tang on immediate and late airway response and leukocyte infiltration in asthmatic guinea pigs
作者:	Kao, ST;Yeh, TJ;Hsieh, CC;Yeh, FT;Lin, JG
貢獻者:	附設醫院;Sch Post Baccalaureate Chinese Med, Dept Immunol & Cellular Physiol, Taichung, Taiwan;China Med Coll Hosp, Taichung, Taiwan;China Med Coll, Res Inst Chinese Med, Taichung, Taiwan
日期:	2000
上傳時間:	2010-09-24 14:16:53 (UTC+8)
出版者:	MARCEL DEKKER INC
摘要:	The pyrogenic response to supernatant fluids obtained from human peripheral blood mononuclear cells (PBMC) stimulated with staphylococcal enterotoxin A (SEA) was characteristic of a response to an endogenous pyrogen in that it was brief and monophasic and,vas destroyed by heating supernatant fluids at 70 degrees C for 30 min. The febrile responses were in parallel with the levels of interleukin-1 (IL-1), tumor necrosis factor (TNF), interferon-gamma (IFN-gamma), IL-2, and IL-6 in supernatant fluids obtained from PBMC treated with SEA. Both the pyrogenicity and the levels of IL-1, TNF, IFN-gamma, IL-2, and IL-6 in supernatant fluids started to rise at 6 to 18 h and reached their peak levels at 24 to 96 h after SEA incubation. Both the fever and the increased levels of IL-1, TNF, IFN-gamma, IL-2, and IL-6 in supernatant fluids obtained from the SEA-stimulated PBMC were decreased by incubating SEA-PBMC with anisomycin (a protein synthesis inhibitor), aminoguanidine (an inhibitor of inducible nitric oxide synthase [NOS]), or dexamethasone (an inhibitor of NOS). The febrile response to supernatant fluids obtained from the SEA-stimulated PBMC was attenuated by adding either anti-IL-1 beta, anti-TNF-alpha, or anti-IFN-gamma monoclonal antibody (MAb) to supernatant fluids. The antipyretic effects exerted by anti-IL-1 beta MAb were greater than those exerted by anti-TNF-alpha or anti-IFN-gamma MAb. The data suggest that SEA acts through the NOS mechanisms in PBMC to stimulate synthesis of pyrogenic cytokines (in particular, the IL-1 beta).
關聯:	IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY 22(1):143-162
顯示於類別:	[台中附設醫院] 期刊論文

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