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請使用永久網址來引用或連結此文件:
http://ir.cmu.edu.tw/ir/handle/310903500/28950
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| 題名: | Distributions of p53 codon 72 polymorphism in bladder cancer - proline form is prominent in invasive tumor |
| 作者: | Chen, WC;Tsai, FJ;Wu, JY;Wu, HC;Lu, HF;Li, CW |
| 貢獻者: | 附設醫院;China Med Coll Hosp, Sch Med, Dept Urol, Taichung, Taiwan;China Med Coll Hosp, Sch Med, Dept Med Genet, Taichung, Taiwan;Natl Tsing Hua Univ, Inst Life Sci, Hsinchu, Taiwan |
| 日期: | 2000 |
| 上傳時間: | 2010-09-24 14:16:49 (UTC+8) |
| 出版者: | SPRINGER-VERLAG |
| 摘要: | In order to investigate the effects of Citrus herbs on cyclosporin absorption and disposition, swine were given cyclosporin (10 mg/kg) with or without decoctions of Citri Aurantii Fructus (CAF) or Citri Grandis Pericarpium (CGP) in a crossover design. FPIA method (fluorescence polarization immunoassay) was used to determine the blood concentration of cyclosporin. The decoctions were characterized by their flavanone contents. Our results indicated that the coadministration of CAF and CGP significantly increased the C-max of cyclosporin by 64% and 79%, respectively. The AUC of cyclosporin was significantly elevated by 97% when coadministered with CGP. Among the swine, 1/5 and 3/5 exhibited acute toxicity of cyclosporin after concomitant intake of CAF and CGP, respectively. This indicates an interaction of Citrus compounds with a commonly used drug. We suggest when cyclosporin is coadministered with these Citrus decoctions, the blood concentration of cyclosporin should be carefully monitored for dose adjustment to avoid cyclosporin intoxication. |
| 關聯: | UROLOGICAL RESEARCH 28(5):293-296 |
| 顯示於類別: | [台中附設醫院] 期刊論文
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