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| 題名: | Evidence for arylamine N-acetyltransferase activity in the bacterium Helicobacter pylori |
| 作者: | Chung, JG;Wang, HH;Tsou, MF;Hsieh, SE;Lo, HH;Yen, YS;Chang, SS;Wu, LT;Lee, JH;Hung, CF |
| 貢獻者: | 附設醫院;CHINA MED COLL HOSP,TAICHUNG,TAIWAN;CHUNG TAI JR MED COLL,TAICHUNG 400,TAIWAN;JEN AI HOSP,DEPT SURG,TAICHUNG,TAIWAN |
| 日期: | 1997 |
| 上傳時間: | 2010-09-24 14:16:41 (UTC+8) |
| 出版者: | ELSEVIER SCI IRELAND LTD |
| 摘要: | Tripterygium wilfordii Hook F (TWH), commonly known as the Thunder-God-Vine, is a popular remedy for rheumatism in southern China. In this study, we investigated the effect of T2 (an extract from TWH) on adjuvant-induced paw oedema in rats and inflammatory mediators. The results showed that an intraperitoneal injection of T2 could significantly decrease the adjuvant-induced paw oedema of rats. During in vitro study, lipopolysaccharide (LPS)-stimulated human mononuclear prostaglandin E(2) (PGE(2)) in the culture supernatant was significantly inhibited by T2 at a concentration of 2 mu g/mL compared with the control group without T2 treatment (22352 +/- 4725 vs 43433 +/- 9014 pg/mL, p < 0.05). When rat neutrophils were treated with 3 mu g/mL of T2, the superoxide production was significantly lower than that of the group without T2 treatment (0.72 +/- 0.07 vs 1.37 +/- 0.04 nmol, p < 0.05). T2 failed to suppress the beta-glucuronidase release from rat neutrophils but when the concentration was 30 mu g/mL, it expressed a significant inhibition of lysozyme release (20.7 +/- 2.9 vs 38.2 +/- 4.0 in the control, p < 0.05). The findings suggest this Chinese herb, like non-steroid antiinflammatory drugs, expresses a potential antiinflammatory effect through its inhibition of PGE(2) and superoxide function and lysozyme release. (C) 1997 by John Wiley & Sons, Ltd. |
| 關聯: | TOXICOLOGY LETTERS 91(1):63-71 |
| 顯示於類別: | [台中附設醫院] 期刊論文
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