Lucidenic acid A (1) and a new lactone, lucidenolactone (2) were isolated from the fruiting bodies of Ganoderma lucidum. Their structures were elucidated by spectroscopic method and single-crystal X-ray analysis. Lucidenolactone (2) showed significant antiplatelet aggregation activity. The NMR spectral data of lucidenic acid A were also reassigned.