Effects of low dose gamma-ray irradiation on peripheral leukocyte counts and spleen of mice

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Title:	Effects of low dose gamma-ray irradiation on peripheral leukocyte counts and spleen of mice
Authors:	Lin, IH;Hau, DM;Chen, WC;Chen, KT
Contributors:	附設醫院;CHINA MED COLL HOSP,CMC,DEPT CHINESE MED,TAICHUNG,TAIWAN
Date:	1996
Issue Date:	2010-09-24 14:16:24 (UTC+8)
Publisher:	CHINESE MEDICAL ASSOCIATION
Abstract:	Aim: To study the restorative effect of Coriolus versicolor polysaccharides (CVP) on spleen injury induced by gamma-ray irradiation in mice. METHODS: ICR male mice, 6 - 8 wk old, were divided at random into 3 groups: A) normal control; B) irradiated with 1 Gy; and C) after 1 Gy irradiation, given CVP 60 mg . g(-1)(ig) daily for 10 d continuously. Body weight (BW), spleen weight (SW), relative SW (RSW), DNA synthesis of splenocytes (DNA-SS), and relative DNA-SS were measured on d 5, 12, 19, 26, and 33 after irradiation. RESULTS: SW, RSW, DNA-SS, and relative DNA-SS decreased after irradiation. CVP enhanced the recovery of SW, RSW, DNA-SS, and relative DNA-SS inhibited by irradiation. CONCLUSION: CVP has the restorative effect against spleen injury induced by gamma-ray irradiation in mice.
Relation:	CHINESE MEDICAL JOURNAL 109(3):210-214
Appears in Collections:	[China Medical University Hospital] Jurnal articles

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