Partially unroofed coronary sinus and persistent left superior vena cava: Intracardiac echocardiographic observation

中國醫藥大學機構典藏 China Medical University Repository, Taiwan > 台中附設醫院 > 期刊論文 > Item 310903500/28937

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题名:	Partially unroofed coronary sinus and persistent left superior vena cava: Intracardiac echocardiographic observation
作者:	Chen, MC;Hung, JS;Chang, KC;Lo, PH;Chen, YC;Fu, M
贡献者:	附設醫院;CHINA MED COLL HOSP,TAICHUNG,TAIWAN;CHANG GUNG MEM HOSP,CARDIOL SECT,KAOHSIUNG,TAIWAN
日期:	1996
上传时间:	2010-09-24 14:16:22 (UTC+8)
出版者:	AMER INST ULTRASOUND MEDICINE
摘要:	Role of neuropeptide Y (NPY) in noradrenergic neurotransmission has been mentioned as co-transmitter in both central and peripheral nervous system. Cerebral NPY content was changed by drugs influencing endogenous norepinephrine (NE) in rats. In an attempt to understand this mechanism, the present study was carried out using the radioimmunoassay of NPY. Values of NPY-like immunoreactivity (NPY-ir) were reduced in rats receiving the treatment of pargyline, the inhibitor of monoamine oxidase, with an elevation of catecholamine in parallel. This action was abolished by pretreatment with a mixture of phentolamine, propranolol and haloperidol at concentration sufficient to block the receptors. However, it was not influenced by treatment with haloperidol alone. Cerebrocortical NPY-ir was lowered in rats receiving an intracerebroventricular (i.c.v.) injection of methoxamine, the agonist of alpha(1)-adrenoceptors, This action was prevented by prazosin via an i.c.v. injection at the dose sufficient to block alpha(1)-adrenoceptors. Moreover, decrease of cerebrocortical NPY-ir by pargyline was also reversed by similar treatment of prazosin. The data obtained suggests that activation of alpha(1)-adrenoceptors by endogenous NE which was increased by pargyline may lower the contents of NPY in cerebrocortex of the rat.
關聯:	JOURNAL OF ULTRASOUND IN MEDICINE 15(12):875-879
显示于类别:	[台中附設醫院] 期刊論文

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